Lars Ulrik Fokdal

Overlæge, Ph.d. Oncology, Sygehus Lillebælt, Vejle Sygehus larfok@rm.dk
Forskningsområde

DK: Gynækologi. Ekstern strålebehandling. Brachyterapi.

UK: Gynaecology. External radiotherapy. Brachytherapy.

 Arbejdsgrupper Publikationer
  • Fokdal L, Tanderup K, Pötter R, Sturdza A, Kirchheiner K, Chargari C, Jürgenliemk-Schulz IM, Segedin B, Tan LT, Hoskin P, Mahantshetty U, Bruheim K, Rai B, Kirisits C, Lindegaard JC; EMBRACE collaborative group. Risk Factors for Ureteral Stricture After Radiochemotherapy Including Image Guided Adaptive Brachytherapy in Cervical Cancer: Results From the EMBRACE Studies Int J Radiat Oncol Biol Phys . 2019 Mar 15;103(4):887-894 2019
  • Sofia Spampinato, Lars U Fokdal, Richard Pötter, Christine Haie-Meder, Jacob C Lindegaard, Maximilian P Schmid, Alina Sturdza, Ina M Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Fleur Huang , Rachel Cooper, Elzbieta van der Steen-Banasik, Erik Van Limbergen, Marit Sundset, Henrike Westerveld, Remi A Nout, Nina B K Jensen, Christian Kirisits, Kathrin Kirchheiner, Kari Tanderup, EMBRACE Collaborative Group Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis Radiother Oncol. 2021 May;158:300-308 2021
  • Nina B K Jensen, Richard Pötter, Sofia Spampinato, Lars U Fokdal, Cyrus Chargari , Jacob C Lindegaard , Maximilian P Schmid, Alina Sturdza, Ina M Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Ericka Wiebe, Rachel Cooper, Elzbieta Van der Steen-Banasik, Erik Van Limbergen, Marit Sundset, Bradley R Pieters, Remi A Nout, Christian Kirisits, Kathrin Kirchheiner, Kari Tanderup, EMBRACE Collaborative Group Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):688-700 2021
  • Sandy Mohamed, Lars Fokdal, Marianne S Assenholt, Jesper Kallehauge, Jacob C Lindegaard, Kari Tanderup Dosimetric impact of edema on inguinal lymph node boost in locally advanced vulvar cancer J Appl Clin Med Phys. 2021 Oct;22(10):315-319 2021
  • Sofia Spampinato, Nina B K Jensen, Richard Pötter, Lars U Fokdal, Cyrus Chargari, Jacob C Lindegaard, Maximilian P Schmid, Alina Sturdza, Ina M Jürgenliemk-Schulz, Umesh Mahantshetty, Peter Hoskin, Barbara Segedin, Bhavana Rai, Kjersti Bruheim, Ericka Wiebe, Elzbieta Van der Steen-Banasik, Rachel Cooper, Erik Van Limbergen, Marit Sundset, Bradley R Pieters, Ludy C H W Lutgens, Li Tee Tan, Elena Villafranca, Stéphanie Smet, Noha Jastaniyah, Remi A Nout, Christian Kirisits, Supriya Chopra, Kathrin Kirchheiner, Kari Tanderup, Embrace Collaborative Group Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future Int J Radiat Oncol Biol Phys. 2022 Mar 1;112(3):681-693 2022
  • Spampinato S, Fokdal LU, Pötter R, Haie-Meder C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van der Steen-Banasik E, Van Limbergen E, Sundset M, Westerveld H, Nout RA, Jensen NBK, Kirisits C, Kirchheiner K, Tanderup K; EMBRACE Collaborative Group. Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: an EMBRACE analysis Radiother Oncol . 2021 May;158:312-320 2021
  • Berger T, Godart J, Jagt T, Vittrup AS, Fokdal LU, Lindegaard JC, Jensen NBK, Zolnay A, Reijtenbagh D, Trnkova P, Tanderup K, Hoogeman M. Dosimetric Impact of Intrafraction Motion in Online-Adaptive Intensity Modulated Proton Therapy for Cervical Cancer Int J Radiat Oncol Biol Phys . 2021 Apr 1;109(5):1580-1587 2021
  • Chopra S, Mangaj A, Sharma A, Tan LT, Sturdza A, Jürgenliemk-Schulz I, Han K, Huang F, Schmid MP, Fokdal L, Chargari C, Diendorfer T, Tanderup K, Potter R, Nout RA Management of oligo-metastatic and oligo-recurrent cervical cancer: A pattern of care survey within the EMBRACE research network Radiother Oncol . 2020 Nov 2;155:151-159. 2020
  • Kirchheiner K, Smet S, Spampinato S, Jensen NBK, Vittrup AS, Fokdal L, Najjari-Jamal D, Westerveld HG, Lindegaard JC, Kirisits C, De Leeuw A, Schmid MP, Tan LT, Nout RA, Jürgenliemk-Schulz IM, Pötter R, Tanderup K Initiatives for education, training, and dissemination of morbidity assessment and reporting in a multiinstitutional international context: Insights from the EMBRACE studies on cervical cancer Brachytherapy . Nov-Dec 2020;19(6):837-849. 2020
  • Tan LT, Tanderup K, Kirisits C, Mahantshetty U, Swamidas J, Jürgenliemk-Schulz I, Lindegaard J, de Leeuw A, Nesvacil N, Assenholt M, Berger D, Diendorfer T, Dimopoulos J, Duke S, Ecker S, Fokdal L, Hellebust T, Jensen N, Kirchheiner K, Nout R, Petric P, Schmid M, Seppenwoolde Y, Sturdza A, Van Limbergen E, Haie-Meder C, Pötter R Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective Brachytherapy . Nov-Dec 2020;19(6):827-836. 2020
  • J Knoth, R Pötter, I M Jürgenliemk-Schulz, C Haie-Meder, L Fokdal, A Sturdza, P Hoskin, U Mahantshetty, B Segedin, K Bruheim, E Wiebe, B Rai, R Cooper, E van der Steen-Banasik , E van Limbergen , B R Pieters, M Sundset, L T Tan, R A Nout, K Tanderup, C Kirisits, N Nesvacil, J C Lindegaard, M P Schmid Clinical and imaging findings in cervical cancer and their impact on FIGO and TNM staging - An analysis from the EMBRACE study Gynecol Oncol . 2020 Oct;159(1):136-141. 2020
  • Tanderup K, Nesvacil N, Kirchheiner K, Serban M, Spampinato S, Jensen NBK, Schmid M, Smet S, Westerveld H, Ecker S, Mahantshetty U, Swamidas J, Chopra S, Nout R, Tan LT, Fokdal L, Sturdza A, Jürgenliemk-Schulz I, de Leeuw A, Lindegaard JC, Kirisits C, Pötter R Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer Semin Radiat Oncol. 2020 Oct;30(4):311-327 2020
  • Vittrup AS, Tanderup K, Bentzen SM, Jensen NBK, Spampinato S, Fokdal LU, Lindegaard JC, Sturdza A, Schmid M, Segedin B, Jürgenliemk-Schulz IM, Bruheim K, Mahantshetty U, Haie-Meder C, Rai B, Cooper R, van der Steen-Banasik E, Sundset M, Huang F, Nout RA, Villafranca E, Van Limbergen E, Pieters BR, Tan LT, Lutgens LCHW, Hoskin P, Pötter R, Kirchheiner K; EMBRACE Collaborative Group. Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study Int J Radiat Oncol Biol Phys . 2021 Jan 1;109(1):161-173 2021
  • Spampinato S, Tanderup K, Marinovskij E, Axelsen S, Pedersen EM, Pötter R, Lindegaard JC, Fokdal L MRI-based contouring of functional sub-structures of the lower urinary tract in gynaecological radiotherapy Radiother Oncol. 2020 Apr;145:117-124 2020
  • Lindegaard JC, Petric P, Lindegaard AM, Tanderup K, Fokdal LU. Evaluation of a new prognostic tumor score in locally advanced cervical cancer integrating clinical examination and magnetic resonance imaging. nt J Radiat Oncol Biol Phys. 2020 Mar 15;106(4):754-763 2020
  • Vittrup AS, Tanderup K, Bentzen SM, Jensen NBK, Spampinato S, Fokdal LU, Lindegaard JC, Sturdza A, Schmid M, Segedin B, Jürgenliemk-Schulz IM, Bruheim K, Mahantshetty U, Haie-Meder C, Rai B, Cooper R, van der Steen-Banasik E, Sundset M, Huang F, Nout RA, Villafranca E, Van Limbergen E, Pieters BR, Tan LT, Lutgens LCHW, Hoskin P, Pötter R, Kirchheiner K; EMBRACE Collaborative Group. Persistence of late substantial patient-reported symptoms (LAPERS) after radiochemotherapy including image-guided adaptive brachytherapy for locally advanced cervical cancer: A report from the EMBRACE study. Int J Radiat Oncol Biol Phys. 2020 Aug 24;S0360-3016(20)34139-0. 2020
  • Berger T, Seppenwoolde Y, Pötter R, Assenholt MS, Lindegaard JC, Nout RA, de Leeuw A, Jürgenliemk-Schulz I, Tan LT, Georg D, Kirisits C, Dumas I, Nesvacil N, Swamidas J, Hudej R, Lowe G, Hellebust TP, Menon G, Fokdal L, Tanderup K; EMBRACE Collaborative Group. Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II. Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):885-894. 2019
  • Fokdal L, Pötter R, Kirchheiner K, Lindegaard JC, Jensen NBK, Kirisits C, Chargari C, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K. Physician assessed and patient reported urinary morbidity after radio-chemotherapy and image guided adaptive brachytherapy for locally advanced cervical cancer. Radiother Oncol. 127(3): 423-430 2018
  • Pötter R, Tanderup K, Kirisits C, de Leeuw A, Kirchheiner K, Nout R, Tan LT, Haie-Meder C, Mahantshetty U, Segedin B, Hoskin P, Bruheim K, Rai B, Huang F, Van Limbergen E, Schmid M, Nesvacil N, Sturdza A, Fokdal L, Jensen NBK, Georg D, Assenholt M, Seppenwoolde Y, Nomden C, Fortin I, Chopra S, van der Heide U, Rumpold T, Lindegaard JC, Jürgenliemk-Schulz I; EMBRACE Collaborative Group. The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies. Clinical and translational Radiation Oncology. 9: 48-60 2018
  • Vittrup AS, Kirchheiner K, Fokdal LU, Bentzen SM, Nout RA, Pötter R, Tanderup K Reporting of Late Morbidity After Radiation Therapy in Large Prospective Studies: A Descriptive Review of the Current Status. Int J Radiat Oncol Biol Phys. 2019 Aug 27. 2019
  • Spampinato S, Fokdal L, Marinovskij E, Axelsen S, Pedersen EM, Pötter R, Lindegaard JC, Tanderup K. Assessment of dose to functional sub-structures in the lower urinary tract in locally advanced cervical cancer radiotherapy. Phys Med. 2019 Mar;59:127-132. 2019
  • Jensen NBK, Pötter R, Kirchheiner K, Fokdal L, Lindegaard JC, Kirisits C, Mazeron R, Mahantshetty U, Jürgenliemk-Schulz IM, Segedin B, Hoskin P, Tanderup K; EMBRACE Collaborative Group. Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study. Radiother Oncol. 2018 Jun; 127(3): 431-439 2018
  • Jensen NBK, Assenholt MS, Fokdal LU, Vestergaard A, Schouboe A, Kjaersgaard EB, Boejen A, Nyvang L, Lindegaard JC, Tanderup K Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer Phys Imaging Radiat Oncol. 2018 Dec 20;9:14-20 2018
  • Berger T, Fokdal LU, Assenholt MS, Jensen NBK, Petersen JBB, Nyvang L, Korreman S, Lindegaard JC, Tanderup K Robustness of elective lymph node target coverage with shrinking Planning Target Volume margins in external beam radiotherapy of locally advanced cervical cancer. Phys Imaging Radiat Oncol. 2019 Jun 26;11:9-15 2019
  • Schmid MP, Fokdal L, Westerveld H, Chargari C, Rohl L, Morice P, Nesvacil N, Mazeron R, Haie-Meder C, Pötter R, Nout RA; GEC-ESTRO GYN Working Group. Recommendations from gynaecological (GYN) GEC-ESTRO working group - ACROP: Target concept for image guided adaptive brachytherapy in primary vaginal cancer Radiother Oncol. 2020 Apr;145:36-44 2020
  • Westerveld H, Nesvacil N, Fokdal L, Chargari C, Schmid MP, Milosevic M, Mahantshetty UM, Nout RA Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer Lancet Oncol. 2020 Mar;21(3):e157-e167 2020
  • Niyoteka S, Berger T, Fokdal LU, Petersen JBB, Zolnay A, Hoogeman M, Tanderup K, Nystrom HU Impact of interfractional target motion in locally advanced cervical cancer patients treated with spot scanning proton therapy using an internal target volume strategy Phys Imaging Radiat Oncol. 2021 Feb 6;17:84-90 2021
  • Peters M, de Leeuw AAC, Nomden CN, Tanderup K, Kirchheiner K, Lindegaard JC, Kirisits C, Haie-Meder C, Sturdza A, Fokdal L, Mahantshetty U, Hoskin P, Segedin B, Bruheim K, Rai B, Huang F, Cooper R, van der Steen-Banasik E, van Limbergen E, Pieters BR, Tan LT, van Rossum PSN, Nesvacil N, Nout R, Schmid MP, Pötter R, Jürgenliemk-Schulz IM; EMBRACE Collaborative Group Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis Radiother Oncol. 2021 Oct;163:150-158 2021
  • Petric P, Lindegaard JC, Sturdza A, Fokdal L, Kirchheiner K, Tan LT, Schmid MP, Haie-Meder C, Jürgenliemk-Schulz IM, van Limbergen E, Hoskin P, Gillham C, Tharavichitkul E, Mahantshetty U, Villafranca E, Tanderup K, Kirisits C, Pötter R Results of image guided brachytherapy for stage IB cervical cancer in the RetroEMBRACE study Radiother Oncol. 2021 Apr;157:24-31 2021
  • Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study Lancet Oncol. 2021 Apr;22(4):538-547 2021
  • Serban M, Fokdal L, Nielsen SK, Hokland SB, Hansen AT, Spejlborg H, Rylander S, Petric P, Lindegaard JC, Tanderup K Characterization of combined intracavitary/interstitial brachytherapy including oblique needles in locally advanced cervix cancer Brachytherapy. 2021 Jul-Aug;20(4):796-806 2021
  • Sturdza AE, Pötter R, Kossmeier M, Kirchheiner K, Mahantshetty U, Haie-Meder C, Lindegaard JC, Jurgenliemk-Schulz I, Tan LT, Hoskin P, van Limbergen E, Gillham C, Segedin B, Tharavichitkul E, Iturre EV, Fokdal LU, Polterauer S, Kirisits C, Tanderup K Nomogram Predicting Overall Survival in Patients With Locally Advanced Cervical Cancer Treated With Radiochemotherapy Including Image-Guided Brachytherapy: A Retro-EMBRACE Study Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):168-177 2021
  • Westerveld H, Schmid MP, Nout RA, Chargari C, Pieters BR, Creutzberg CL, Sturdza A, Lindegaard JC, van Kesteren Z, Mazeron R, Nesvacil N, Fokdal LU Image-Guided Adaptive Brachytherapy (IGABT) for Primary Vaginal Cancer: Results of the International Multicenter RetroEMBRAVE Cohort Study Cancers (Basel). 2021 Mar 23;13(6):1459 2021
  • Lindegaard JC, Petric P, Schmid MP, Nesvacil N, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Kirchheiner K, Spampinato S, Jürgenliemk-Schulz I, Tanderup K, Kirisits C, Pötter R Prognostic Implications of Uterine Cervical Cancer Regression During Chemoradiation Evaluated by the T-Score in the Multicenter EMBRACE I Study Int J Radiat Oncol Biol Phys. 2022 Jun 1;113(2):379-389 2022
  • Kirchheiner K, Smet S, Jürgenliemk-Schulz IM, Haie-Meder C, Chargari C, Lindegaard JC, Fokdal LU, Spampinato S, Schmid MP, Sturdza A, Mahantshetty U, Segedin B, Bruheim K, Rai B, Cooper R, Van der Steen-Banasik E, Wiebe E, Sundset M, van Limbergen E, Villafranca E, Westerveld H, Tan LT, Pötter R, Tanderup K, Nout RA; EMBRACE Collaborative Group Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):400-413 2022
  • Kamrava M, Leung E, Bachand F, Beriwal S, Chargari C, D'Souza D, Erickson B, Fokdal L, Han K, Harkenrider M, Lin L, Mahantshetty U, Nesvacil N, Ravi A, Schmid M, Vigneault E, Westerveld H, Yashar C, Nout R GEC-ESTRO (ACROP)-ABS-CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina Int J Radiat Oncol Biol Phys. 2022 Oct 1:S0360-3016(22)03396-X 2022
  • Glatzer M, Tanderup K, Rovirosa A, Fokdal L, Ordeanu C, Tagliaferri L, Chargari C, Strnad V, Dimopoulos JA, Šegedin B, Cooper R, Nakken ES, Petric P, van der Steen-Banasik E, Lössl K, Jürgenliemk-Schulz IM, Niehoff P, Hermansson RS, Nout RA, Putora PM, Plasswilm L, Tselis N Role of Brachytherapy in the Postoperative Management of Endometrial Cancer: Decision-Making Analysis among Experienced European Radiation Oncologists. Cancers (Basel). 2022 Feb 11;14(4):906 2022
  • Fokdal L, Jensen PT, Wulff C, Sanggaard MA, Hae M, Niemann I, Hansen ES, Lindegaard JC Lichen Sclerosis is Associated With a High Rate of Local Failure After Radio(chemo)therapy for Vulvar Cancer Clin Oncol (R Coll Radiol). 2022 Jan;34(1):3-10 2022