
DK: Funktionel imaging med særlig fokus på onkologisk PET. Udvikling og evaluering af hypoksi-selektive sporstoffer ved hjælp af forsøg i cellesystemer og tumorbærende mus med henblik på at kunne a) påvise og kvantificere mikromiljø-relaterede resistensproblemer før behandling igangsættes, b) evaluere anvendeligheden af PET til at guide optimalt behandlingsvalg, herunder muligheden for at modificere stråleterapi (hel-tumor dosis-eskalation eller dose painting) eller supplere med medikamentel hypoksisk intervention, c) evaluere behandlingseffektivitet tidligt efter behandlingsstart.
UK: Functional imaging with a special focus on oncological PET. Development and evaluation of hypoxia selective trace element by means of experiments in cell systems and tumor-bearing mice for the purpose of a) showing and quantifying microenvironment-related resistant problems before treatment start, b) evaluate the utility of PET to guide optimal treatment choice, including the opportunity to modify radiotherapy (whole-tumor dose-escalation or dose painting) or complement with medicamentary hypoxic intervention, c) evaluating treatment effectivity early after treatment start.
Publikationer- Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts Cancers (Basel) . 2021 May 26;13(11):2602 2021
- Therapeutic Modification of Hypoxia Clin Oncol (R Coll Radiol) . 2021 Nov;33(11):e492-e509 2021
- Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions Semin Nucl Med. 2020 Nov;50(6):562-583. 2020
- Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts. Acta Oncol. 2019 Oct;58(10):1489-1494. 2019
- Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes. Acta Oncol. 2019 Oct;58(10):1476-1482. 2019
- APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells. Cell Chem Biol. 2018 Nov 15;25(11):1337-1349.e12 2018