Mike Horsman

Professor in Experimental Radiotherapy Experimental Clinical Oncology, Aarhus University Hospital mike@oncology.au.dk
Forskningsområde

DK: Studier relateret til tumor vaskulatur og mikromiljøet. Tumor vaskulatur handler om brugen af vaskuløs målrettede behandlinger (for eksempel, medicin og hypertermi), mens mikromiljøet primært fokuserer på hypoksi med hensyn til dens betydning inden for radioterapi, målinger og hvordan man eliminerer den ved at bruge klinisk relevante terapier.  

UK: Studies related to the tumor vasculature and microenvironment. The former include the use of vascular targeting therapies (i.e., drugs and hyperthermia), while the latter primarily focusses on hypoxia in terms of its significance for radiation therapy, its measurement, and how to eliminate it using clinically relevant therapies.

 Arbejdsgrupper Publikationer
  • Elming PB, Wittenborn TR, Busk M, Sørensen BS, Thomsen MBH, Strandgaard T, Dyrskjøt L, Nielsen S, Horsman MR Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts Cancers (Basel) . 2021 May 26;13(11):2602 2021
  • Horsman MR, Sørensen BS, Busk M, Siemann DW Therapeutic Modification of Hypoxia Clin Oncol (R Coll Radiol) . 2021 Nov;33(11):e492-e509 2021
  • Elming PB, Sørensen BS, Spejlborg H, Overgaard J, Horsman MR Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone? Int J Hyperthermia . 2021;38(1):105-110 2021
  • Sørensen BS, Horsman MR Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways Front Oncol . 2020 Apr 21;10:562 2020
  • Nielsen S, Bassler N, Grzanka L, Swakon J, Olko P, Horsman MR, Sørensen BS Proton Scanning and X-ray Beam Irradiation Induce Distinct Regulation of Inflammatory Cytokines in a Preclinical Mouse Model Int J Radiat Biol. 2020 Oct;96(10):1238-1244. 2020
  • Busk M, Overgaard J, Horsman MR Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions Semin Nucl Med. 2020 Nov;50(6):562-583. 2020
  • Busk M, Horsman MR, Overgaard J, Jakobsen S. Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes. Acta Oncol. 2019 Oct;58(10):1476-1482. 2019
  • Elming PB, Sørensen BS, Oei AL, Franken NAP, Crezee J, Overgaard J, Horsman MR Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia. Cancers (Basel). 2019 Jan 9;11(1). 2019
  • Jacobsen KM, Villadsen NL, Tørring T, Nielsen CB, Salomón T, Nielsen MM, Tsakos M, Sibbersen C, Scavenius C, Nielsen R, Christensen EI, Guerra PF, Bross P, Pedersen JS, Enghild JJ, Johannsen M, Frøkiær J, Overgaard J, Horsman MR, Busk M, Poulsen TB APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells. Cell Chem Biol. 2018 Nov 15;25(11):1337-1349.e12 2018
  • Oei AL, Kok HP, Oei SB, Horsman MR, Stalpers LJA, Franken NAP, Crezee J. Molecular and biological rationale of hyperthermia as radio- and chemosensitizer Adv Drug Deliv Rev. 2020;163-164:84-97 2020
  • Ademaj A, Veltsista PD, Marder D, Hälg RA, Puric E, Brunner TB, Crezee H, Gabrys D, Franckena M, Gani C, Horsman MR, Krempien R, Lindner LH, Maluta S, Notter M, Petzold G, Abdel-Rahman S, Richetti A, Thomsen AR, Tsoutsou P, Fietkau R, Ott OJ, Ghadjar P, Riesterer O A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers Strahlenther Onkol. 2022 Aug 29 2022