Cai Grau

Professor Dept. of Oncology, Aarhus University Hospital cai@oncology.au.dk
Research interests

DK: Hoved-halskræft. Strålebehandling og partikelterapi, sundhedsøkonomi, senfølger, nationalt og internationalt samarbejde.

UK: Head and neck cancer. Radiotherapy and particle therapy, health economics, late effects, national and international collaboration.

 Workgroups Publications
  • Høyer M, Grau C, Overgaard J No time to die - BiGART is back. The 20th Acta Oncologica Symposium - BIGART 2021 Acta Oncol . 2022 Feb;61(2):117-119 2022
  • Sharma MB, Jensen K, Friborg J, Smulders B, Andersen E, Samsøe E, Johansen J, Hansen CR, Andersen M, Nielsen MS, Filtenborg MV, Ren J, Korreman SS, Overgaard J, Grau C Target coverage and local recurrences after radiotherapy for sinonasal cancer in Denmark 2008-2015. A DAHANCA study Acta Oncol . 2022 Feb;61(2):120-126 2022
  • R Argota-Perez, M B Sharma, U V Elstrøm, D S Møller, C Grau, K Jensen, A I S Holm, S S Korreman Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer Radiother Oncol. 2022 Aug;173:102-108 2022
  • Jensen K, Al-Farra G, Dejanovic D, Eriksen JG, Loft A, Hansen CR, Pameijer FA, Zukauskaite R, Grau C. Imaging for Target Delineation in Head and Neck Cancer Radiotherapy Semin Nucl Med. 2021 Jan;51(1):59-67. 2021
  • Sharma MB, Argota Perez R, Holm AIS, Korreman SS, Jensen K, Elstrøm UV, Grau C. Air variability in maxillary sinus during radiotherapy for sinonasal carcinoma Clin Transl Radiat Oncol. 2021 Jan 1;27:36-43. 2021
  • Henthorn NT, Sokol O, Durante M, De Marzi L, Pouzoulet F, Miszczyk J, Olko P, Brandenburg S, van Goethem MJ, Barazzuol L, Tambas M, Langendijk JA, Davídková M, Vondráček V, Bodenstein E, Pawelke J, Lomax A, Weber DC, Dasu A,Sternlöw B, Poulsen PR, Sørensen BS, Grau C, Sitarz MK, Heuskin AC, Lucas S, Warmenhoven JW, Merchant MJ, Mackay RI, Kirkby KJ. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Front Phys 2020: 8; 565055. 2020
  • Poulsen PR, Murtaza G, Worm ES, Ravkilde T, O'Brien R, Grau C, Høyer M, Keall P Simulated multileaf collimator tracking for stereotactic liver radiotherapy guided by kilovoltage intrafraction monitoring: Dosimetric gain and target overdose trends Radiother Oncol 2020: 144; 93-100 2020
  • Witt Nyström P, Bratland Å, Minn H, Grau C Ongoing and future clinical trials in particle therapy in the Nordic countries Acta Oncol. 2020 Oct;59(10):1145-1150 2020
  • Sharma MB, Jensen K, Urbak SF, Funding M, Johansen J, Bechtold D, Amidi A, Eskildsen SF, Jørgensen JOL, Grau C A multidimensional cohort study of late toxicity after intensity modulated radiotherapy for sinonasal cancer Radiother Oncol. 2020 Oct;151:58-65 2020
  • Sharma MB, Jensen K, Amidi A, Eskildsen SF, Johansen J, Grau C Late toxicity in the brain after radiotherapy for sinonasal cancer: Neurocognitive functioning, MRI of the brain and quality of life Clin Transl Radiat Oncol. 2020 Sep 12;25:52-60. 2020
  • Lievens Y, Borras JM, Grau C Provision and use of radiotherapy in Europe Mol Oncol. 2020 Jul;14(7):1461-1469. 2020
  • Grau C, Durante M, Georg D, Langendijk JA, Weber DC. Particle therapy in Europe Mol Oncol. 2020 Jul;14(7):1492-1499. 2020
  • Jensen K, Friborg J, Hansen CR, Samsøe E, Johansen J, Andersen M, Smulders B, Andersen E, Nielsen MS, Eriksen JG, Petersen JBB, Elstrøm UV, Holm AI, Farhadi M, Morthorst MH, Skyt PS, Overgaard J, Grau C The danish head and neck cancer group (DAHANCA) 2020 radiotherapy guidelines. Radiother Oncol. 2020 Aug 8;151:149-151. 2020
  • Worm ES, Høyer M, Hansen R, Larsen LP, Weber B, Grau C, Poulsen PR. A Prospective Cohort Study of Gated Stereotactic Liver Radiation Therapy Using Continuous Internal Electromagnetic Motion Monitoring. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):366-375 2018
  • Andreassen CN, Eriksen JG, Jensen K, Hansen CR, Sørensen BS, Lassen P, Alsner J, Schack LMH, Overgaard J, Grau C. IMRT - Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer. Oral Oncol. 2018 Nov;86:91-99. 2018
  • Zukauskaite R, Hansen CR, Grau C, Samsøe E, Johansen J, Petersen JBB, Andersen E, Brink C, Overgaard J, Eriksen JG Local recurrences after curative IMRT for HNSCC: Effect of different GTV to high-dose CTV margins. Radiother Oncol. 2018 Jan;126(1):48-55. 2018
  • Hansen CR, Friborg J, Jensen K, Samsøe E, Johnsen L, Zukauskaite R, Grau C, Maare C, Johansen J, Primdahl H, Bratland Å, Kristensen CA, Andersen M, Eriksen JG, Overgaard J NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy. Acta Oncol. 2019 Oct;58(10):1410-1415. 2019
  • Mortensen HR, Høyer M, Grau C. Proton therapy Ugeskr Laeger. 2019 Oct 14;181(20A). 2019
  • Overgaard J, Muren LP, Høyer M, Grau C BIGART 2019 - adapting to the future. Acta Oncol. 2019 Oct;58(10):1323-1327. 2019
  • Farr KP, Khalil AA, Grau C Patient-reported lung symptoms and quality of life before and after radiation therapy for non-small cell lung cancer: correlation with radiation pneumonitis and functional imaging. Acta Oncol. 2019 Oct;58(10):1523-1527 2019
  • Korreman S, Eriksen JG, Grau C. The changing role of radiation oncology professionals in a world of AI - Just jobs lost - Or a solution to the under-provision of radiotherapy? Clin Transl Radiat Oncol. 2020 Sep 17;26:104-107 2021
  • Chan J, Friborg J, Chernov M, Cherkashin M, Grau C, Brundage M, Slotman B Access to radiotherapy among circumpolar Inuit populations. Lancet Oncol. 2019 Oct;20(10):e590-e600 2019
  • Chan J, Friborg J, Zubizarreta E, van Eck JW, Hanna TP, Bourque JM, Gaudet M, Dennis K, Olson R, Coleman CN, Petersen AJ, Grau C, Abdel-Wahab M, Brundage M, Slotman B, Polo A Examining geographic accessibility to radiotherapy in Canada and Greenland for indigenous populations: Measuring inequities to inform solutions. Radiother Oncol. 2020 May;146:1-8 2020
  • Borras JM, Grau C, Corral J, Wong K, Barton MB, Ferlay J, Bray F, Lievens Y. Estimating the number of fractions by tumour site for European countries in 2012 and 2025: An ESTRO-HERO analysis Radiother Oncol. 2018 Feb;126(2):198-204 2018
  • Farr KP, Khalil AA, Møller DS, Bluhme H, Kramer S, Morsing A, Grau C. Time and dose-related changes in lung perfusion after definitive radiotherapy for NSCLC Radiother Oncol. 2018 Feb;126(2):307-311 2018
  • Grau C, Baumann M, Weber DC Optimizing clinical research and generating prospective high-quality data in particle therapy in Europe: Introducing the European Particle Therapy Network (EPTN) Radiother Oncol. 2018 Jul;128(1):1-3 2018
  • Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines Radiother Oncol. 2018 Jan;126(1):3-24 2018
  • Grégoire V, Grau C, Lapeyre M, Maingon P. Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma. Oral Oncol. 2018 Dec;87:131-137 2018
  • Grégoire V, Grau C In reply to "A Long-Awaited Guideline for the Delineation of Primary Tumor in Head and Neck Cancer, and a Few Concerns about It" by Sezin Yuce Sari et al. Radiother Oncol. 2018 Jun;127(3):508 2018
  • Hansen CR, Johansen J, Samsøe E, Andersen E, Petersen JBB, Jensen K, Andersen LJ, Sand HMB, Bertelsen AS, Grau C Consequences of introducing geometric GTV to CTV margin expansion in DAHANCA contouring guidelines for head and neck radiotherapy Radiother Oncol. 2018 Jan;126(1):43-47 2018
  • Hvid CA, Elstrøm UV, Jensen K, Grau C Cone-beam computed tomography (CBCT) for adaptive image guided head and neck radiation therapy Acta Oncol. 2018 Apr;57(4):552-556 2018
  • Langendijk JA, Orecchia R, Haustermans K, Zips D, Balosso J, Lacombe D, Lievens Y, Weber DC, Grau C, Troost EGC Prospective data registration and clinical trials for particle therapy in Europe Radiother Oncol. 2018 Jul;128(1):9-13 2018
  • Overgaard J, Hoff CM, Hansen HS, Specht L, Overgaard M, Lassen P, Andersen E, Johansen J, Andersen LJ, Evensen JF, Alsner J, Grau C. DAHANCA 10 - Effect of darbepoetin alfa and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. A multicenter, open-label, randomized, phase 3 trial by the Danish head and neck cancer group. Radiother Oncol. 2018 Apr;127(1):12-19 2018
  • Taasti VT, Muren LP, Jensen K, Petersen JBB, Thygesen J, Tietze A, Grau C, Hansen DC Comparison of single and dual energy CT for stopping power determination in proton therapy of head and neck cancer. Phys Imaging Radiat Oncol. 2018 Apr 22;6:14-19 2018
  • Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update Radiother Oncol. 2019 May;134:1-9. 2019
  • Defourny N, Monten C, Grau C, Lievens Y, Perrier L ritical review and quality-assessment of cost analyses in radiotherapy: How reliable are the data? Radiother Oncol. 2019 Dec;141:14-26 2019
  • Defourny N, Perrier L, Borras JM, Coffey M, Corral J, Hoozée S, Loon JV, Grau C, Lievens Y. National costs and resource requirements of external beam radiotherapy: A time-driven activity-based costing model from the ESTRO-HERO project Radiother Oncol. 2019 Sep;138:187-194 2019
  • Lee AW, Ng WT, Pan JJ, Chiang CL, Poh SS, Choi HC, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Sanguineti G, Soong YL, Tao Y, Yom SS, Wee JT. International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma Int J Radiat Oncol Biol Phys. 2019 Nov 1;105(3):567-580 2019
  • Lievens Y, Audisio R, Banks I, Collette L, Grau C, Oliver K, Price R, Aggarwal A. Towards an evidence-informed value scale for surgical and radiation oncology: a multi-stakeholder perspective. Lancet Oncol. 2019 Feb;20(2):e112-e123 2019
  • Lievens Y, Grau C, Aggarwal A. Value-based health care - what does it mean for radiotherapy? Acta Oncol. 2019 Oct;58(10):1328-1332 2019
  • Weber DC, Grau C, Lim PS, Georg D, Lievens Y Bringing Europe together in building clinical evidence for proton therapy - the EPTN-ESTRO-EORTC endeavor Acta Oncol. 2019 Oct;58(10):1340-1342 2019
  • Gerlach S, Pinto M, Kurichiyanil N, Grau C, Hérault J, Hillbrand M, Poulsen PR, Safai S, Schippers JM, Schwarz M, Søndergaard CS, Tommasino F, Verroi E, Vidal M, Yohannes I, Schreiber J, Parodi K Beam characterization and feasibility study for a small animal irradiation platform at clinical proton therapy facilities Phys Med Biol. 2020 Dec 22;65(24):245045 2020
  • Lievens Y, Defourny N, Corral J, Gasparotto C, Grau C, Borras JM; ESTRO–HERO Consortium Collaborators. How public health services pay for radiotherapy in Europe: an ESTRO-HERO analysis of reimbursement Lancet Oncol. 2020 Jan;21(1):e42-e54 2020
  • Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; . Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol. 2020 Nov;31(11):1462-1475 2020
  • Thomas G, Eisenhauer E, Bristow RG, Grau C, Hurkmans C, Ost P, Guckenberger M, Deutsch E, Lacombe D, Weber DC; European Organisation for Research and Treatment of Cancer (EORTC). The European Organisation for Research and Treatment of Cancer, State of Science in radiation oncology and priorities for clinical trials meeting report Eur J Cancer. 2020 May;131:76-88 2020
  • Eriksen JG, Johansen J, Godballe C, Kjærgaard T, Primdahl H, Charabi B, Andersen E, Farhadi M, Kristensen CA, Lyhne N, Andersen M, Grau C, Høyrup M, Hvass SA, Overgaard J Danish Head & Neck Cancer group (DAHANCA) kvalitetsdatabase - Resumé af årsrapport 2020 Ugeskr Læg 2021. 2021
  • Høyer M, Grau C Research in radiation oncology and the Covid-19 pandemic Acta Oncol. 2021 Mar;60(3):275-276 2021
  • Khalil AA, Hau E, Gebski V, Grau C, Gee H, Nyeng TB, West K, Kramer S, Farlow D, Knap M, Møller DS, Hoffmann L, Farr KP. Personal innovative approach in radiation therapy of lung cancer- functional lung avoidance SPECT-guided (ASPECT) radiation therapy: a study protocol for phase II randomised double-blind clinical trial BMC Cancer. 2021 Aug 21;21(1):940 2021
  • Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group Radiother Oncol. 2021 Mar;156:281-293 2021
  • Lievens Y, Borras JM, Grau C, Aggarwal A Value-based radiotherapy: A new chapter of the ESTRO-HERO project Radiother Oncol. 2021 Jul;160:236-239 2021
  • Nyeng TB, Møller DS, Farr K, Kramer S, Khalil AA, Grau C, Hoffmann L A comparison of two methods for segmentation of functional volumes in radiotherapy planning of lung cancer patients Acta Oncol. 2021 Mar;60(3):353-360 2021
  • Petit C, Lacas B, Pignon JP, Le QT, Grégoire V, Grau C, Hackshaw A, Zackrisson B, Parmar MKB, Lee JW, Ghi MG, Sanguineti G, Temam S, Cheugoua-Zanetsie M, O'Sullivan B, Posner MR, Vokes EE, Cruz Hernandez JJ, Szutkowski Z, Lartigau E, Budach V, Suwiński R, Poulsen M, Kumar S, Ghosh Laskar S, Mazeron JJ, Jeremic B, Simes J, Zhong LP, Overgaard J, Fortpied C, Torres-Saavedra P, Bourhis J, Aupérin A, Blanchard P; MACH-NC and MARCH Collaborative Groups Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis Lancet Oncol. 2021 May;22(5):727-736 2021
  • Sørensen BS, Sitarz MK, Ankjærgaard C, Johansen JG, Andersen CE, Kanouta E, Grau C, Poulsen P Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model Radiother Oncol. 2022 Oct;175:178-184 2022
  • Singers Sørensen B, Krzysztof Sitarz M, Ankjærgaard C, Johansen J, Andersen CE, Kanouta E, Overgaard C, Grau C, Poulsen P In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH Radiother Oncol. 2022 Feb;167:109-115 2022
  • Laskar SG, Sinha S, Krishnatry R, Grau C, Mehta M, Agarwal JP Access to Radiation Therapy: From Local to Global and Equality to Equity JCO Glob Oncol. 2022 Aug;8:e2100358 2022