Carsten Brink

Professor, medical physics Radiofysisk laboratorium, Odense University Hospital
Research interests

DK: Forskningsområder dækker blandt andet Radiomics (udtræk af biologisk information fra medicinske billeder) samt statistisk modellering af tumor kontrol og normalvævs skade.

UK: Research areas cover Radiomics (extract of biological information from medical images) and statistical modelling of tumour control and normal tissue damage. 

Workgroups Publications
  • Bernchou U, Christiansen RL, Bertelsen A, Tilly D, Riis HL, Jensen HR, Mahmood F, Hansen CR, Hansen VN, Schytte T, Brink C End-to-end validation of the geometric dose delivery performance of MR linac adaptive radiotherapy Phys Med Biol . 2021 Feb 12;66(4):045034 2021
  • Christiansen RL, Johansen J, Zukauskaite R, Hansen CR, Bertelsen AS, Hansen O, Mahmood F, Brink C, Bernchou U Accuracy of automatic structure propagation for daily magnetic resonance image-guided head and neck radiotherapy Acta Oncol . 2021 May;60(5):589-597 2021
  • Christiansen RL, Dysager L, Hansen CR, Jensen HR, Schytte T, Nyborg CJ, Bertelsen AS, Agergaard SN, Mahmood F, Hansen S, Hansen O, Brink C, Bernchou U Online adaptive radiotherapy potentially reduces toxicity for high-risk prostate cancer treatment Radiother Oncol . 2022 Feb;167:165-171 2022
  • Brink C, Bernchou U, Bertelsen A, Hansen O, Schytte T, Hjelmborg JVB, Holloway L, van Herk M, Johnson-Hart C, Price GJ, Aznar MC, McWilliam A, Faivre-Finn C, Hansen CR Causal relation between heart irradiation and survival of lung cancer patients after radiotherapy Radiother Oncol . 2022 Jul;172:126-133 2022
  • Bisgaard ALH, Brink C, Fransen ML, Schytte T, Behrens CP, Vogelius I, Nissen HD, Mahmood F Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation Phys Imaging Radiat Oncol. 2022 Mar 7;21:146-152 2022
  • Laugaard Lorenzen E, Christian Rehammar J, Jensen MB, Ewertz M, Brink C Radiation-induced risk of ischemic heart disease following breast cancer radiotherapy in Denmark, 1977-2005 Radiother Oncol . 2020 Nov;152:103-110 2020
  • van Timmeren JE, van Elmpt W, de Ruysscher D, Reymen B, Hansen O, Brink C Tumor regression during radiotherapy for non-small cell lung cancer patients using cone-beam computed tomography images Strahlenther Onkol. 2020 Feb;196(2):159-171. 2020
  • Hansen CR, Bertelsen A, Zukauskaite R, Johnsen L, Bernchou U, Thwaites DI, Eriksen JG, Johansen J, Brink C Prediction of radiation-induced mucositis of H&N cancer patients based on a large patient cohort Radiother Oncol. 2020 Jun;147:15-21. 2020
  • Christiansen RL, Hansen CR, Dahlrot RH, Bertelsen A, Hansen O, Brink C, Bernchou U. Plan quality for high-risk prostate cancer treated with high field magnetic resonance imaging guided radiotherapy. Physics and Imaging in Radiation Oncology, 7, 1-8. 2018
  • Zukauskaite R, Hansen CR, Grau C, Samsøe E, Johansen J, Petersen JBB, Andersen E, Brink C, Overgaard J, Eriksen JG Local recurrences after curative IMRT for HNSCC: Effect of different GTV to high-dose CTV margins. Radiother Oncol. 2018 Jan;126(1):48-55. 2018
  • Bertelsen AS, Schytte T, Møller PK, Mahmood F, Riis HL, Gottlieb KL, Agergaard SN, Dysager L, Hansen O, Gornitzka J, Veldhuizen E, ODwyer DB, Christiansen RL, Nielsen M, Jensen HR, Brink C, Bernchou U First clinical experiences with a high field 1.5 T MR linac. Acta Oncol. 2019 Oct;58(10):1352-1357. 2019
  • Brink C, Lorenzen EL, Krogh SL, Westberg J, Berg M, Jensen I, Thomsen MS, Yates ES, Offersen BV DBCG hypo trial validation of radiotherapy parameters from a national data bank versus manual reporting. Acta Oncol. 2018 Jan;57(1):107-112. 2018
  • Aarup-Kristensen S, Hansen CR, Forner L, Brink C, Eriksen JG, Johansen J Osteoradionecrosis of the mandible after radiotherapy for head and neck cancer: risk factors and dose-volume correlations. Acta Oncol. 2019 Oct;58(10):1373-1377. 2019
  • Kaae JK, Stenfeldt L, Hyrup B, Brink C, Eriksen JG A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum. Radiother Oncol. 2019 Oct 9. 2019
  • Kaae JK, Johnsen L, Hansen CR, Kristensen MH, Brink C, Eriksen JG Relationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy. Acta Oncol. 2019 Oct;58(10):1366-1372. 2019
  • Mahmood F, Nielsen UG, Jørgensen CB, Brink C, Thomsen HS, Hansen RH Safety of gadolinium based contrast agents in magnetic resonance imaging-guided radiotherapy - An investigation of chelate stability using relaxometry Phys Imaging Radiat Oncol. 2022 Feb 26;21:96-100 2022
  • Bernchou U, Arnold TST, Axelsen B, Klüver-Kristensen M, Mahmood F, Harbo FSG, Asmussen JT, Hansen O, Bertelsen AS, Hansen S, Brink C, Dahlrot RH Evolution of the gross tumour volume extent during radiotherapy for glioblastomas Radiother Oncol. 2021 Jul;160:40-46 2021
  • Hasler SW, Bernchou U, Bertelsen A, van Veldhuizen E, Schytte T, Hansen VN, Brink C, Mahmood F Tumor-site specific geometric distortions in high field integrated magnetic resonance linear accelerator radiotherapy Phys Imaging Radiat Oncol . 2020 Aug 19;15:100-104 2020
  • Zukauskaite R, Rumley CN, Hansen CR, Jameson MG, Trada Y, Johansen J, Gyldenkerne N, Eriksen JG, Aly F, Christensen RL, Lee M, Brink C, Holloway L Delineation uncertainties of tumour volumes on MRI of head and neck cancer patients Clinical and Translational Radiation Oncology. September 2022, Pages 121-126 2022
  • Jeppesen SS, Matzen LE, Brink C, Bliucukiene R, Kasch S, Schytte T, Kristiansen C, Hansen O Impact of comprehensive geriatric assessment on quality of life, overall survival, and unplanned admission in patients with non-small cell lung cancer treated with stereotactic body radiotherapy J Geriatr Oncol. 2018 Nov;9(6):575-582 2018
  • Breast cancer patients report reduced sensitivity and pain using a barrier film during radiotherapy - A Danish intra-patient randomized multicentre study. Tech Innov Patient Support Radiat Oncol. 2018 Jun 19;7:20-25 2018
  • van Timmeren JE, van Elmpt W, Leijenaar RTH, Reymen B, Monshouwer R, Bussink J, Paelinck L, Bogaert E, De Wagter C, Elhaseen E, Lievens Y, Hansen O, Brink C, Lambin P Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence Radiother Oncol. 2019 Jul;136:78-85 2019
  • Christiansen RL, Dysager L, Bertelsen AS, Hansen O, Brink C, Bernchou U. Accuracy of automatic deformable structure propagation for high-field MRI guided prostate radiotherapy Radiat Oncol. 2020 Feb 7;15(1):32. 2020
  • Finnegan R, Lorenzen E, Dowling J, Holloway L, Thwaites D, Brink C Localised delineation uncertainty for iterative atlas selection in automatic cardiac segmentation Phys Med Biol. 2020 Feb 4;65(3):035011 2020
  • Lutz CM, Knap MM, Hoffmann L, Møller DS, Hansen O, Brink C, Schytte T, Nyhus CH, McCulloch T, Borissova S, Alber M, Khalil AA Prospectively scored pulmonary toxicities in non-small cell lung cancer: Results from a randomized phase II dose escalation trial Clin Transl Radiat Oncol. 2020 Nov 26;27:8-14 2020
  • Rai R, Holloway LC, Brink C, Field M, Christiansen RL, Sun Y, Barton MB, Liney GP Multicenter evaluation of MRI-based radiomic features: A phantom study Med Phys. 2020 Jul;47(7):3054-3063 2020
  • Engstrøm KH, Brink C, Nielsen MH, Kjellgren M, Gottlieb K, Hazell I, Hansen VN, Lorenzen EL Automatic treatment planning of VMAT for left-sided breast cancer with lymph nodes Acta Oncol. 2021 Nov;60(11):1425-1431 2021
  • Ewertz M, Ehmsen S, Jørgensen TL, Dieperink K, Pfeiffer P, Hansen O, Brink C, Hjelmborg J, Hvidt NC, Abildgaard N, Lund L, Frederiksen H, Ryg J, Ditzel HJ Challenges in cancer treatment for the elderly Ugeskr Laeger. 2021 Sep 27;183(39):V04210325 2021
  • Finnegan R, Laugaard Lorenzen E, Dowling J, Thwaites D, Delaney G, Brink C, Holloway L. Validation of a new open-source method for automatic delineation and dose assessment of the heart and LADCA in breast radiotherapy with simultaneous uncertainty estimation Phys Med Biol. 2021 Jan 26;66(3):035014 2021
  • Nielsen TB, Brink C, Jeppesen SS, Schytte T, Hansen O, Nielsen M. umour motion analysis from planning to end of treatment course for a large cohort of peripheral lung SBRT targets Acta Oncol. 2021 Nov;60(11):1407-1412 2021
  • Bertelsen A, Bernchou U, Schytte T, Brink C, Mahmood F The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy Phys Imaging Radiat Oncol. 2022 Nov 15;24:167-172 2022
  • Rai R, Barton MB, Chlap P, Liney G, Brink C, Vinod S, Heinke M, Trada Y, Holloway LC Repeatability and reproducibility of magnetic resonance imaging-based radiomic features in rectal cancer J Med Imaging (Bellingham). 2022 Jul;9(4):044005 2022
  • Hansen CR, Price G, Field M, Sarup N, Zukauskaite R, Johansen J, Eriksen JG, Aly F, McPartlin A, Holloway L, Thwaites D, Brink C Larynx cancer survival model developed through open-source federated learning Radiother Oncol. 2022 Nov;176:179-186 2022
  • Brink C, Hansen CR, Field M, Price G, Thwaites D, Sarup N, Bernchou U, Holloway L Distributed learning optimisation of Cox models can leak patient data: Risks and solutions arXiv:2204.05856 2020