Per Poulsen

Professor Department of Oncology, Aarhus University Hospital per.poulsen@rm.dk
Research interests

DK: Billedstyret stråleterapi, real-tids behandling adaption, dosis rekonstruktion, bevægelses behandling. 

UK: Image-guided radiotherapy, real-time treatment adaptation, dose reconstruction, motion management.

Workgroups Publications
  • Møller DS, Poulsen PR, Hagner A, Dufour M, Nordsmark M, Nyeng TB, Mortensen HR, Lutz CM, Hoffmann L Strategies for Motion Robust Proton Therapy With Pencil Beam Scanning for Esophageal Cancer Int J Radiat Oncol Biol Phys . 2021 Oct 1;111(2):539-548 2021
  • Worm ES, Hansen R, Høyer M, Weber B, Mortensen H, Poulsen PR Uniform versus non-uniform dose prescription for proton stereotactic body radiotherapy of liver tumors investigated by extensive motion-including treatment simulations Phys Med Biol . 2021 Oct 12;66(20) 2021
  • Muurholm CG, Ravkilde T, Skouboe S, Worm E, Hansen R, Høyer M, Keall PJ, Poulsen PR Real-time dose-guidance in radiotherapy: Proof of principle Radiother Oncol . 2021 Nov;164:175-182 2021
  • Kanouta E, Johansen JG, Kertzscher G, Sitarz MK, Sørensen BS, Poulsen PR Time structure of pencil beam scanning proton FLASH beams measured with scintillator detectors and compared with log files Med Phys . 2022 Mar;49(3):1932-1943 2022
  • Muurholm CG, Ravkilde T, De Roover R, Skouboe S, Hansen R, Crijns W, Depuydt T, Poulsen PR Experimental investigation of dynamic real-time rotation-including dose reconstruction during prostate tracking radiotherapy Med Phys . 2022 Jun;49(6):3574-3584 2022
  • Kim JH, Nguyen DT, Booth JT, Huang CY, Fuangrod T, Poulsen P, O'Brien R, Caillet V, Eade T, Kneebone A, Keall P. The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments Radiother Oncol. 2018 Feb;126(2):236-243. 2018
  • Keall PJ, Nguyen DT, O'Brien R, Zhang P, Bertholet J, Poulsen PR. In Reply to Dahele and Verbakel Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):283-284. 2019
  • Ravkilde T, Skouboe S, Hansen R, Worm E, Poulsen PR. First online real-time evaluation of motion-induced 4D dose errors during radiotherapy delivery. Med Phys 2018: 45; 3893-3903. 2018
  • Muurholm CG, Ravkilde T, Skouboe S, Eade T, Nguyen DT, Booth J, Keall PJ, Poulsen PR. Dose reconstruction including dynamic six-degree of freedom motion during prostate radiotherapy. J Phys Conf Ser 2019: 1305; 012053. 2019
  • Poulsen PR, Eley J, Langner U, Simone CB 2nd, Langen K. Efficient Interplay Effect Mitigation for Proton Pencil Beam Scanning by Spot-Adapted Layered Repainting Evenly Spread out Over the Full Breathing Cycle Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):226-234. 2018
  • Keall PJ, Nguyen DT, O'Brien R, Caillet V, Hewson E, Poulsen PR, Bromley R, Bell L, Eade T, Kneebone A, Martin J, Booth JT. The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator Radiother Oncol. 2018 Apr;127(1):6-11. 2018
  • Keall PJ, Nguyen DT, O'Brien R, Zhang P, Happersett L, Bertholet J, Poulsen PR. Review of Real-Time 3-Dimensional Image Guided Radiation Therapy on Standard-Equipped Cancer Radiation Therapy Systems: Are We at the Tipping Point for the Era of Real-Time Radiation Therapy? Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):922-931. 2018
  • Caillet V, O'Brien R, Moore D, Poulsen P, Pommer T, Colvill E, Sawant A, Booth J, Keall P. Technical Note: In silico and experimental evaluation of two leaf-fitting algorithms for MLC tracking based on exposure error and plan complexity Med Phys. 2019 Apr;46(4):1814-1820. 2019
  • Keall P, Poulsen P, Booth JT. See, Think, and Act: Real-Time Adaptive Radiotherapy Semin Radiat Oncol. 2019 Jul;29(3):228-235. 2019
  • Bertholet J, Knopf A, Eiben B, McClelland J, Grimwood A, Harris E, Menten M, Poulsen P, Nguyen DT, Keall P, Oelfke U. Real-time intrafraction motion monitoring in external beam radiotherapy Phys Med Biol. 2019 Aug 7;64(15):15TR01. 2019
  • Keall P, Nguyen DT, O'Brien R, Hewson E, Ball H, Poulsen P, Booth J, Greer P, Hunter P, Wilton L, Bromley R, Kipritidis J, Eade T, Kneebone A, Hruby G, Moodie T, Hayden A, Turner S, Arumugam S, Sidhom M, Hardcastle N, Siva S, Tai KH, Gebski V, Martin J. Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):530-538. 2020
  • Booth J, Caillet V, Briggs A, Hardcastle N, Angelis G, Jayamanne D, Shepherd M, Podreka A, Szymura K, Nguyen DT, Poulsen P, O'Brien R, Harris B, Haddad C, Eade T, Keall P. MLC tracking for lung SABR is feasible, efficient and delivers high-precision target dose and lower normal tissue dose Radiother Oncol. 2020 Nov 3;155:131-137. 2020
  • Skouboe S, De Roover R, Muurholm CG, Ravkilde T, Crijns W, Hansen R, Depuydt T, Poulsen PR. Six degrees of freedom dynamic motion-including dose reconstruction in a commercial treatment planning system Med Phys. 2021 Jan 8. 2021
  • Keall PJ, Colvill E, O'Brien R, Caillet V, Eade T, Kneebone A, Hruby G, Poulsen PR, Zwan B, Greer PB, Booth J. Electromagnetic-Guided MLC Tracking Radiation Therapy for Prostate Cancer Patients: Prospective Clinical Trial Results Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):387-395. 2018
  • Lydiard S, Caillet V, Ipsen S, O'Brien R, Blanck O, Poulsen PR, Booth J, Keall P. Investigating multi-leaf collimator tracking in stereotactic arrhythmic radioablation (STAR) treatments for atrial fibrillation Phys Med Biol. 2018 Sep 28;63(19):195008. 2018
  • Mylonas A, Keall PJ, Booth JT, Shieh CC, Eade T, Poulsen PR, Nguyen DT. A deep learning framework for automatic detection of arbitrarily shaped fiducial markers in intrafraction fluoroscopic images Med Phys. 2019 May;46(5):2286-2297. 2019
  • Hewson EA, Nguyen DT, O'Brien R, Kim JH, Montanaro T, Moodie T, Greer PB, Hardcastle N, Eade T, Kneebone A, Hruby G, Hayden AJ, Turner S, Siva S, Tai KH, Hunter P, Sams J, Poulsen PR, Booth JT, Martin J, Keall PJ. The accuracy and precision of the KIM motion monitoring system used in the multi-institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy with KIM (SPARK) trial Med Phys. 2019 Nov;46(11):4725-4737. 2019
  • Keall PJ, Sawant A, Berbeco RI, Booth JT, Cho B, Cerviño LI, Cirino E, Dieterich S, Fast MF, Greer PB, Munck Af Rosenschöld P, Parikh PJ, Poulsen PR, Santanam L, Sherouse GW, Shi J, Stathakis S. AAPM Task Group 264: The Safe Clinical Implementation of MLC Tracking in Radiotherapy Med Phys. 2020 Dec 1. 2021
  • Vanhanen A, Poulsen P, Kapanen M. Dosimetric effect of intrafraction motion and different localization strategies in prostate SBRT Phys Med. 2020 Jun 12;75:58-68. 2020
  • Henthorn NT, Sokol O, Durante M, De Marzi L, Pouzoulet F, Miszczyk J, Olko P, Brandenburg S, van Goethem MJ, Barazzuol L, Tambas M, Langendijk JA, Davídková M, Vondráček V, Bodenstein E, Pawelke J, Lomax A, Weber DC, Dasu A,Sternlöw B, Poulsen PR, Sørensen BS, Grau C, Sitarz MK, Heuskin AC, Lucas S, Warmenhoven JW, Merchant MJ, Mackay RI, Kirkby KJ. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Front Phys 2020: 8; 565055. 2020
  • Jaccard M, Ehrbar S, Miralbell R, Hagen T, Koutsouvelis N, Poulsen P, Rouzaud M, Tanadini-Lang S, Tsoutsou P, Guckenberger M, Zilli T. Single-fraction prostate stereotactic body radiotherapy: Dose reconstruction with electromagnetic intrafraction motion tracking Radiother Oncol. 2020 Dec 11;156:145-152. 2020
  • Anastasi G, Bertholet J, Poulsen P, Roggen T, Garibaldi C, Tilly N, Booth JT, Oelfke U, Heijmen B, Aznar MC. Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part I: Intra-fraction breathing motion management Radiother Oncol. 2020 Dec;153:79-87. 2020
  • Hewson EA, Nguyen DT, O'Brien R, Poulsen PR, Booth JT, Greer P, Eade T, Kneebone A, Hruby G, Moodie T, Hayden AJ, Turner SL, Hardcastle N, Siva S, Tai KH, Martin J, Keall PJ. Is multileaf collimator tracking or gating a better intrafraction motion adaptation strategy? An analysis of the TROG 15.01 stereotactic prostate ablative radiotherapy with KIM (SPARK) trial Radiother Oncol. 2020 Oct;151:234-241. 2020
  • Hewson EA, Ge Y, O'Brien R, Roderick S, Bell L, Poulsen PR, Eade T, Booth JT, Keall PJ, Nguyen DT. Adapting to the motion of multiple independent targets using multileaf collimator tracking for locally advanced prostate cancer: Proof of principle simulation study Med Phys. 2020 Oct 30. 2020
  • De Roover R, Hansen R, Crijns W, Muurholm CG, Poels K, Skouboe S, Haustermans K, Poulsen PR, Depuydt T. Dosimetric impact of intrafraction prostate rotation and accuracy of gating, multi-leaf collimator tracking and couch tracking to manage rotation: An end-to-end validation using volumetric film measurements Radiother Oncol. 2020 Nov 29;156:10-18. 2020
  • Poulsen PR, Murtaza G, Worm ES, Ravkilde T, O'Brien R, Grau C, Høyer M, Keall P Simulated multileaf collimator tracking for stereotactic liver radiotherapy guided by kilovoltage intrafraction monitoring: Dosimetric gain and target overdose trends Radiother Oncol 2020: 144; 93-100 2020
  • Poulsen PR, Thomsen MS, Hansen R, Worm E, Spejlborg H, Offersen B Fully automated detection of heart irradiation in cine MV images acquired during breast cancer radiotherapy Radiother Oncol 2020: 152; 189-190 2020
  • Nankali S, Worm ES, Hansen R, Weber B, Høyer M, Zirak A, Poulsen PR Geometric and dosimetric comparison of four intrafraction motion adaptation strategies for stereotactic liver radiotherapy Phys Med Biol 2018: 63; 145010 2018
  • Hansen AT, Poulsen PR, Høyer M, Worm ES Isotoxic dose prescription level strategies for stereotactic liver radiotherapy: the price of dose uniformity Acta Oncol 2020: 59: 558-64 2020
  • Skouboe S, Poulsen PR, Muurholm CG, Worm E, Hansen R, Høyer M, Ravkilde T. Simulated real-time dose reconstruction for moving tumors in stereotactic liver radiotherapy. Med Phys 2019: 46; 4738-4748. 2019
  • Jensen SV, Valdetaro LB, Poulsen PR, Balling P, Petersen JBB, Muren LP Dose-response of deformable radiochromic dosimeters for spot scanning proton therapy Phys Imaging Radiat Oncol. 2020 Nov 20;16:134-137 2020
  • Toftegaard J, Keall PJ, O'Brien R, Ruan D, Ernst F, Homma N, Ichiji K, Poulsen PR. Potential improvements of lung and prostate MLC tracking investigated by treatment simulations. Med Phys. 2018 May;45(5):2218-2229. 2018
  • Worm ES, Høyer M, Hansen R, Larsen LP, Weber B, Grau C, Poulsen PR. A Prospective Cohort Study of Gated Stereotactic Liver Radiation Therapy Using Continuous Internal Electromagnetic Motion Monitoring. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):366-375 2018
  • D. Sloth Møller, M.L. Schmidt, T. Ravkilde, P.R. Poulsen, J. Hansen, E.S. Worm, H.H. Schmidt, M.M. Knap, A. Safwat, H.K. Rose, L. Hoffmann Intra-fractional stability of deep inspiration breath hold during rt for lung and lymphoma cancer. Radiotherapy and Oncology Volume 133, Supplement 1, April 2019, Pages S531-S532 2019
  • Colvill E, Petersen JBB, Hansen R, Worm E, Skouboe S, Høyer M, Poulsen PR. Validation of fast motion-including dose reconstruction for proton scanning therapy in the liver. Phys Med Biol. 63(22):225021 2018
  • Skouboe S, Ravkilde T, Bertholet J, Hansen R, Worm ES, Muurholm CG, Weber B, Høyer M, Poulsen PR. First clinical real-time motion-including tumor dose reconstruction during radiotherapy delivery. Radiother Oncol. 2019 Oct;139:66-71. 2019
  • Hoffmann L, Poulsen PR, Ravkilde T, Bertholet J, Kruhlikava I, Helbo BL, Schmidt ML, Nordsmark M. Setup strategies and uncertainties in esophageal radiotherapy based on detailed intra- and interfractional tumor motion mapping. Radiother Oncol. 2019 Jul;136:161-168. 2019
  • Bertholet J, Toftegaard J, Hansen R, Worm ES, Wan H, Parikh PJ, Weber B, Høyer M, Poulsen PR. Automatic online and real-time tumour motion monitoring during stereotactic liver treatments on a conventional linac by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK). Phys Med Biol. 63(5); pp. 055012 2018
  • Schmidt ML, Hoffmann L, Møller DS, Knap MM, Rasmussen TR, Folkersen BH, Poulsen PR. Systematic intrafraction shifts of mediastinal lymph node targets between setup imaging and radiation treatment delivery in lung cancer patients. Radiother Oncol. 126 (2), pp. 318-324. 2018