Karen-Lise Spindler

Professor Oncology, Aarhus University Hospital k.g.spindler@rm.dk
Research interests

DK: Vi arbejder med precisions medicin ved gastrointestinal cancer, her med specielt fokus på stråleterapi ved rectum og anal cancer samt klinisk anvendelse af cirkulerende DNA og andre biomarkører.

UK: We work with precision medicine at gastrointestinal cancer, especially focusing on radiotherapy at the rectum and anal cancer and clinical use of circulating DNA and other biomarkers. 

Workgroups Publications
  • Lefèvre AC, Alsner J, Sørensen BS, Tramm T, Toustrup K, Overgaard J, Spindler KG Hypoxia and local tumour control in squamous cell carcinoma of the anus - a hypothesis-generating study Acta Oncol . 2022 Jun 22;1-4 2022
  • Boysen AK, Pallisgaard N, Andersen CSA, Spindler KG Circulating tumor DNA as a marker of minimal residual disease following local treatment of metastases from colorectal cancer. Acta Oncol. 2020 Aug 13;1-6. 2020
  • Lefèvre AC, Kronborg C, Sørensen BS, Krag SRP, Serup-Hansen E, Spindler KG. Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence. Radiother Oncol . 2020 Jul 3;150:211-216. 2020
  • Boysen AK, Ording AG, Astradsson A, Høyer M, Spindler KL Metastasis directed treatment of brain metastases from colorectal cancer - a Danish population-based cohort study. Acta Oncol . 2020 Sep;59(9):1118-1122. 2020
  • Boysen AK, Spindler KL, Høyer M, Mortensen FV, Christensen TD, Farkas DK, Ording AG. Metastasis directed therapy for liver and lung metastases from colorectal cancer-A population-based study. Int J Cancer. 2018 Dec 15;143(12):3218-3226. 2018
  • Boysen AK, Sørensen BS, Lefevre AC, Abrantes R, Johansen JS, Jensen BV, Schou JV, Larsen FO, Nielsen D, Taflin H, Gustavson B, Wettergren Y, Sorensen BS, Ree AH, Dueland S, Pallisgaard N, Spindler KL Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer. Clin Chim Acta. 2018 Dec;487:107-111. 2018
  • Truelsen CG, Kronborg CS, Sørensen BS, Callesen LB, Spindler KG Circulating cell-free DNA as predictor of pathological complete response in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy Clin Transl Radiat Oncol. 2022 Jun 8;36:9-15 2022
  • Wind KL, Serup-Hansen E, Havelund BM, Riber L, Kronborg CJS, Jakobsen A, Spindler KG Definitive therapy for squamous cell carcinoma of the anus with synchronous metastases - a report from the Danish Anal Cancer Group Acta Oncol . 2022 Mar;61(3):321-327 2022
  • Wind KL, Riber L, Havelund BM, Serup-Hansen E, Kronborg C, Fode MM, Jakobsen A, Spindler KG Intensified Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Anus-A Population-Based Experience from the Danish Anal Cancer Group ancers (Basel) . 2021 Jun 28;13(13):3226 2021
  • Lefèvre AC, Pallisgaard N, Kronborg C, Wind KL, Krag SRP, Spindler KG The Clinical Value of Measuring Circulating HPV DNA during Chemo-Radiotherapy in Squamous Cell Carcinoma of the Anus Cancers (Basel) . 2021 May 18;13(10):2451 2021
  • Kronborg CJS, Christensen P, Pedersen BG, Spindler KG Anorectal function and radiation dose to pelvic floor muscles after primary treatment for anal cancer Radiother Oncol . 2021 Apr;157:141-146 2021
  • Schou JV, Larsen FO, Sørensen BS, Abrantes R, Boysen AK, Johansen JS, Jensen BV, Nielsen DL, Spindler KL. Circulating cell-free DNA as predictor of treatment failure after neoadjuvant chemo-radiotherapy before surgery in patients with locally advanced rectal cancer. Ann Oncol. 2018 Mar 1;29(3):610-615 2018
  • Appelt AL, Kerkhof EM, Nyvang L, Harderwijk EC, Abbott NL, Teo M, Peters FP, Kronborg CJS, Spindler KG, Sebag-Montefiore D, Marijnen CAM; STAR-TREC collaborative group. Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer - A multicentre dose planning study. Tech Innov Patient Support Radiat Oncol. 2019 Oct 15;11:14-21 2019
  • Boysen AK, Schou JV, Spindler KG Cell-free DNA and preoperative chemoradiotherapy for rectal cancer: a systematic review Clin Transl Oncol. 2019 Jul;21(7):874-880 2019
  • Kronborg CJS, Jørgensen JB, Petersen JBB, Nyvang Jensen L, Iversen LH, Pedersen BG, Spindler KG. Pelvic insufficiency fractures, dose volume parameters and plan optimization after radiotherapy for rectal cancer. Clin Transl Radiat Oncol. 2019 Sep 10;19:72-76 2019
  • Marijnen CAM, Peters FP, Rödel C, Bujko K, Haustermans K, Fokas E, Glynne-Jones R, Valentini V, Spindler KG, Guren MG, Maingon P, Calvo FA, Pares O, Glimelius B, Sebag-Montefiore D International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic Radiother Oncol. 2020 Jul;148:213-215 2020
  • Guren MG, Sebag-Montefiore D, Franco P, Johnsson A, Segelov E, Deutsch E, Rao S, Spindler KG, Arnold D Treatment of Squamous Cell Carcinoma of the Anus, Unresolved Areas and Future Perspectives for Research: Perspectives of Research Needs in Anal Cancer. Clin Colorectal Cancer. 2021 Dec;20(4):279-287 2021
  • Haas S, Mikkelsen AH, Kronborg C, Oggesen BT, Faaborg PM, Serup-Hansen E, Spindler KG, Christensen P Management of late adverse effects after chemoradiation for anal cancer Acta Oncol. 2021 Dec;60(12):1688-1701 2021
  • Rønde HS, Kallehauge JF, Kronborg CJS, Nyvang L, Rekstad BL, Hanekamp BA, Appelt AL, Guren MG, Spindler KLS Intensity modulated proton therapy planning study for organ at risk sparing in rectal cancer re-irradiation Acta Oncol. 2021 Nov;60(11):1436-1439 2021
  • Petric P, Al-Hammadi N, Spindler KG, Lindegaard JC Anal cancer brachytherapy: From radon seeds to interstitial Papillon technique in a century. What does the future hold? Radiother Oncol. 2022 Apr;169:25-34 2022
  • Lefèvre AC, Serup-Hansen E, Storm KS, Wind KL, Kronborg C, Spindler KG One-Year Treatment-Related Side Effects and Quality of Life After Chemoradiotherapy in Squamous Cell Carcinoma of the Anus Int J Radiat Oncol Biol Phys. 2022 Sep 28:S0360-3016(22)03395-8 2022