Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer - A multicentre dose planning study.

Authors Appelt AL, Kerkhof EM, Nyvang L, Harderwijk EC, Abbott NL, Teo M, Peters FP, Kronborg CJS, Spindler KG, Sebag-Montefiore D, Marijnen CAM; STAR-TREC collaborative group.

Source Tech Innov Patient Support Radiat Oncol. 2019 Oct 15;11:14-21 Publicationdate 01 Jan 0001

Abstract

Background and purpose: Organ preservation strategies are increasingly being explored for early rectal cancer. This requires revision of target volumes according to disease stage, as well as new guidelines for treatment planning. We conducted an international, multicentre dose planning study to develop robust planning objectives for modern radiotherapy of a novel mesorectal-only target volume, as implemented in the STAR-TReC trial (NCT02945566).

Materials and methods: The published literature was used to establish relevant dose levels for organ at risk (OAR) plan optimisation. Ten representative patients with early rectal cancer were identified. Treatment scans had mesorectal target volumes as well as bowel cavity, bladder and femoral heads outlined, and were circulated amongst the three participating institutions. Each institution produced plans for short course (SCRT, 5 × 5 Gy) and long course (LCRT, 25 × 2 Gy) treatment, using volumetric modulated arc therapy on different dose planning systems. Optimisation objectives for OARs were established by determining dose metric objectives achievable for ≥90% of plans.

Results: Sixty plans, all fulfilling target coverage criteria, were produced. The planning results and literature review suggested optimisation objectives for SCRT: V _10Gy < 180 cm³, V _18Gy < 110 cm³, V_23Gy < 85 cm³ for bowel cavity; V _21Gy < 15% and V _25Gy < 5% for bladder; and V _12.5Gy < 11% for femoral heads. Corresponding objectives for LCRT: V _20Gy < 180 cm³, V _30Gy < 130 cm³, V _45Gy < 90 cm³ for bowel cavity; V _35Gy < 22% and V _50Gy < 7% for bladder; and V _25Gy < 15% for femoral heads. Constraints were validated across all three institutions.

Conclusion: We utilized a multicentre planning study approach to develop robust planning objectives for mesorectal radiotherapy for early rectal cancer.