DK: Jeg har en stor interesse i stråleterapi i gynækologisk kræft. Jeg er formand for GEC ESTRO gyn arbejdsgruppen og er også i koordinator gruppen i EMBRACE studiet (embracestudy.dk). Jeg er især engageret i at udvikle en forbedret forståelse af udviklingen af toksicitet og sygdomsudfald og derudover engageret i forståelsen af relationen mellem klinisk udfald og patient/behandlings karakteristika. Samtidig er jeg interesseret i brachyterapi teknologi. Jeg koordinerer internationale indsatser for at facilitere og promovere in vivo dosimetri gennem netværksmøder, fælles forskningsaktiviteter og samarbejder med industri for at understøtte at forbedret teknologi kan blive tilgængelig for patienter.
UK: I have a major interest in gynaecological cancer radiotherapy. I am chairing the GEC ESTRO gyn working group, and I am in the EMBRACE study coordinator group (www.embracestudy.dk). I am particularly engaged in developing improved understanding development of toxicity and disease outcome and to understand the relation between clinical outcome and patient/treatment characteristics. Furthermore, I am interested in brachytherapy technology. I am coordinating international efforts to facilitate and promote in vivo dosimetry through network meetings, joint research activities, and collaboration with industry to support that improved technology can become available for patients.
Workgroups Publications- Risk Factors for Ureteral Stricture After Radiochemotherapy Including Image Guided Adaptive Brachytherapy in Cervical Cancer: Results From the EMBRACE Studies Int J Radiat Oncol Biol Phys . 2019 Mar 15;103(4):887-894 2019
- Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis Radiother Oncol. 2021 May;158:300-308 2021
- Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):688-700 2021
- Accuracy of an in vivo dosimetry-based source tracking method for afterloading brachytherapy - A phantom study Med Phys. 2021 May;48(5):2614-2623 2021
- Dosimetric impact of edema on inguinal lymph node boost in locally advanced vulvar cancer J Appl Clin Med Phys. 2021 Oct;22(10):315-319 2021
- A high-Z inorganic scintillator-based detector for time-resolved in vivo dosimetry during brachytherapy Med Phys. 2021 Nov;48(11):7382-7398 2021
- Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future Int J Radiat Oncol Biol Phys. 2022 Mar 1;112(3):681-693 2022
- 3D dose reconstruction based on in vivo dosimetry for determining the dosimetric impact of geometric variations in high-dose-rate prostate brachytherapy Radiother Oncol. 2022 Jun;171:62-68 2022
- Toward 3D dose verification of an electronic brachytherapy source with a plastic scintillation detector Med Phys. 2022 May;49(5):3432-3443 2022
- Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: an EMBRACE analysis Radiother Oncol . 2021 May;158:312-320 2021
- Future directions of in vivo dosimetry for external beam radiotherapy and brachytherapy Physics and Imaging in Radiation Oncology, 2020, 16, pp. 18-19 2020
- In vivo dosimetry in brachytherapy: Requirements and future directions for research, development, and clinical practice Physics and Imaging in Radiation Oncology, 2020, 16, pp. 1-11 2020
- Dosimetric Impact of Intrafraction Motion in Online-Adaptive Intensity Modulated Proton Therapy for Cervical Cancer Int J Radiat Oncol Biol Phys . 2021 Apr 1;109(5):1580-1587 2021
- Management of oligo-metastatic and oligo-recurrent cervical cancer: A pattern of care survey within the EMBRACE research network Radiother Oncol . 2020 Nov 2;155:151-159. 2020
- Initiatives for education, training, and dissemination of morbidity assessment and reporting in a multiinstitutional international context: Insights from the EMBRACE studies on cervical cancer Brachytherapy . Nov-Dec 2020;19(6):837-849. 2020
- Phantom-based quality assurance for multicenter quantitative MRI in locally advanced cervical cancer Radiother Oncol . 2020 Dec;153:114-121 2020
- Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective Brachytherapy . Nov-Dec 2020;19(6):827-836. 2020
- Clinical and imaging findings in cervical cancer and their impact on FIGO and TNM staging - An analysis from the EMBRACE study Gynecol Oncol . 2020 Oct;159(1):136-141. 2020
- Image guidance in radiation therapy for better cure of cancer Mol Oncol . 2020 Jul;14(7):1470-1491. 2020
- Implementing an online radiotherapy quality assurance programme with supporting continuous medical education - report from the EMBRACE-II evaluation of cervix cancer IMRT contouring Radiother Oncol . 2020 Jun;147:22-29. 2020
- A Cost-Utility Analysis of Magnetic Resonance (MR) Guided Brachytherapy Versus Two-Dimensional and Computed Tomography (CT) Guided Brachytherapy for Locally Advanced Cervical Cancer Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):512-521 2020
- Dose planning variations related to delineation variations in MRI-guided brachytherapy for locally advanced cervical cancer Brachytherapy. Mar-Apr 2020;19(2):146-153 2020
- Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer Semin Radiat Oncol. 2020 Oct;30(4):311-327 2020
- Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study Int J Radiat Oncol Biol Phys . 2021 Jan 1;109(1):161-173 2021
- Time-resolved in vivo dosimetry for source tracking in brachytherapy Brachytherapy. 2018 Jan - Feb; 17(1): 122-132 2018
- Dwell time verification in brachytherapy based on time resolved in vivo dosimetry Phys Med. 2019 Apr;60:156-161. 2019
- 3D source tracking and error detection in HDR using two independent scintillator dosimetry systems Med Phys . 2021 May;48(5):2095-2107 2021
- Late, persistent, substantial, treatment-related symptoms after radiotherapy (LAPERS): A new method for longitudinal analysis of late morbidity - applied in the EMBRACE study Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):300-309 2020
- MRI-based contouring of functional sub-structures of the lower urinary tract in gynaecological radiotherapy Radiother Oncol. 2020 Apr;145:117-124 2020
- Ring Versus Ovoids and Intracavitary Versus Intracavitary-Interstitial Applicators in Cervical Cancer Brachytherapy: Results From the EMBRACE I Study. Int J Radiat Oncol Biol Phys. 2020 Apr 1;106(5):1052-1062. 2020
- Evaluation of a new prognostic tumor score in locally advanced cervical cancer integrating clinical examination and magnetic resonance imaging. nt J Radiat Oncol Biol Phys. 2020 Mar 15;106(4):754-763 2020
- Image registration, contour propagation and dose accumulation of external beam and brachytherapy in gynecological radiotherapy. Radiother Oncol. 2020 Feb;143:1-11 2020
- Persistence of late substantial patient-reported symptoms (LAPERS) after radiochemotherapy including image-guided adaptive brachytherapy for locally advanced cervical cancer: A report from the EMBRACE study. Int J Radiat Oncol Biol Phys. 2020 Aug 24;S0360-3016(20)34139-0. 2020
- Importance of training in external beam treatment planning for locally advanced cervix cancer: Report from the EMBRACE II dummy run. Radiother Oncol. 2019 Apr;133:149-155. 2019
- Image-guided Adaptive Brachytherapy for Cervix Cancer - A Story of Successful Collaboration within the GEC-ESTRO GYN Network and the EMBRACE Studies. Clin Oncol (R Coll Radiol). 2018 Jul;30(7):397-399. 2018
- Treatment delivery verification in brachytherapy: Prospects of technology innovation. Brachytherapy. 2018 Jan - Feb;17(1):1-6. 2018
- Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II. Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):885-894. 2019
- Physician assessed and patient reported urinary morbidity after radio-chemotherapy and image guided adaptive brachytherapy for locally advanced cervical cancer. Radiother Oncol. 127(3): 423-430 2018
- Physician assessed and patient reported lower limb edema after definitive radio(chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: A report from the EMBRACE study. Radiother Oncol. 127(3), pp. 449-455 2018
- The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies. Clinical and translational Radiation Oncology. 9: 48-60 2018
- Fatigue, insomnia and hot flashes after definitive radiochemotherapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: An analysis from the EMBRACE study. Radiother Oncol. 127(3): pp. 440-448 2018
- Reporting of Late Morbidity After Radiation Therapy in Large Prospective Studies: A Descriptive Review of the Current Status. Int J Radiat Oncol Biol Phys. 2019 Aug 27. 2019
- Isodose surface volumes in cervix cancer brachytherapy: Change of practice from standard (Point A) to individualized image guided adaptive (EMBRACE I) brachytherapy. Radiother Oncol. 129 (3), pp. 567-574 2018
- Assessment of dose to functional sub-structures in the lower urinary tract in locally advanced cervical cancer radiotherapy. Phys Med. 2019 Mar;59:127-132. 2019
- Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study. Radiother Oncol. 2018 Jun; 127(3): 431-439 2018
- Needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer evaluated by repeated MRI. Brachytherapy. 2018 Jan-Feb;17(1):50-58 2018
- Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer Phys Imaging Radiat Oncol. 2018 Dec 20;9:14-20 2018
- Technique adaptation, strategic replanning, and team learning during implementation of MR-guided brachytherapy for cervical cancer. Brachytherapy. 2018 Jan-Feb;17(1):86-93 2018
- Image-guided Adaptive Brachytherapy for Cervix Cancer - A Story of Successful Collaboration within the GEC-ESTRO GYN Network and the EMBRACE Studies Clin Oncol (R Coll Radiol). 2018 Jul;30(7):397-399 2018
- Robustness of elective lymph node target coverage with shrinking Planning Target Volume margins in external beam radiotherapy of locally advanced cervical cancer. Phys Imaging Radiat Oncol. 2019 Jun 26;11:9-15 2019
- Management of Nodal Disease in Advanced Cervical Cancer Semin Radiat Oncol. 2019 Apr;29(2):158-165 2019
- Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort Radiother Oncol. 2019 May;134:185-190 2019
- Change in Patterns of Failure After Image-Guided Brachytherapy for Cervical Cancer: Analysis From the RetroEMBRACE Study Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):895-902 2019
- IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer Radiother Oncol. 2021 Jul;160:273-284 2021
- Impact of interfractional target motion in locally advanced cervical cancer patients treated with spot scanning proton therapy using an internal target volume strategy Phys Imaging Radiat Oncol. 2021 Feb 6;17:84-90 2021
- Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis Radiother Oncol. 2021 Oct;163:150-158 2021
- Results of image guided brachytherapy for stage IB cervical cancer in the RetroEMBRACE study Radiother Oncol. 2021 Apr;157:24-31 2021
- MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study Lancet Oncol. 2021 Apr;22(4):538-547 2021
- Vaginal dose-surface maps in cervical cancer brachytherapy: Methodology and preliminary results on correlation with morbidity Brachytherapy. 2021 May-Jun;20(3):565-575 2021
- Characterization of combined intracavitary/interstitial brachytherapy including oblique needles in locally advanced cervix cancer Brachytherapy. 2021 Jul-Aug;20(4):796-806 2021
- Risk Factors for Late Persistent Fatigue After Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: An Analysis From the EMBRACE-I Study Int J Radiat Oncol Biol Phys. 2022 Apr 1;112(5):1177-1189 2021
- Nomogram Predicting Overall Survival in Patients With Locally Advanced Cervical Cancer Treated With Radiochemotherapy Including Image-Guided Brachytherapy: A Retro-EMBRACE Study Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):168-177 2021
- Impact of transitioning to an online course - A report from the ESTRO gyn teaching course Clin Transl Radiat Oncol. 2021 Jun 15;29:85-92 2021
- Dosimetric impact of target definition in brachytherapy for cervical cancer - Computed tomography and trans rectal ultrasound versus magnetic resonance imaging Phys Imaging Radiat Oncol. 2022 Mar 4;21:126-133 2022
- Exclusive 3D-brachytherapy as a good option for stage-I inoperable endometrial cancer: a retrospective analysis in the gynaecological cancer GEC-ESTRO Working Group Clin Transl Oncol. 2022 Feb;24(2):254-265 2022
- Prognostic Implications of Uterine Cervical Cancer Regression During Chemoradiation Evaluated by the T-Score in the Multicenter EMBRACE I Study Int J Radiat Oncol Biol Phys. 2022 Jun 1;113(2):379-389 2022
- Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):400-413 2022
- Role of Brachytherapy in the Postoperative Management of Endometrial Cancer: Decision-Making Analysis among Experienced European Radiation Oncologists. Cancers (Basel). 2022 Feb 11;14(4):906 2022