Morten Høyer

Chief physician, professor Danish Centre for Particle Therapy, Aarhus University Hospital hoyer@aarhus.rm.dk
Research interests

DK: Stereotaktisk strålebehandling af hjerne-, lunge- og levertumorer; radioterapi af hjernetumorer, prostata- og blærekræft, radioterapi af børn og unge og protonterapi; forskning i biologi, teknologi og kliniske aspekter inden for stereotaktisk strålebehandling, adaptive radioterapi; specielt fokus på udvikling af stråleskade, kliniske forsøg og protonterapi.

UK: Stereotactic radiotherapy of brain-, lung- and liver tumours; radiotherapy of brain tumours, prostate- and bladder cancer, radiotherapy of children and the young and proton therapy; research in biology, technology and clinical aspects within stereotactic radiotherapy, adaptive radiotherapy; especially focus on the development of radiation injury, clinical trials and proton therapy. 

 Workgroups Publications
  • Worm ES, Hansen R, Høyer M, Weber B, Mortensen H, Poulsen PR Uniform versus non-uniform dose prescription for proton stereotactic body radiotherapy of liver tumors investigated by extensive motion-including treatment simulations Phys Med Biol . 2021 Oct 12;66(20) 2021
  • Muurholm CG, Ravkilde T, Skouboe S, Worm E, Hansen R, Høyer M, Keall PJ, Poulsen PR Real-time dose-guidance in radiotherapy: Proof of principle Radiother Oncol . 2021 Nov;164:175-182 2021
  • Høyer M, Grau C, Overgaard J No time to die - BiGART is back. The 20th Acta Oncologica Symposium - BIGART 2021 Acta Oncol . 2022 Feb;61(2):117-119 2022
  • Toussaint L, Indelicato DJ, Muren LP, Li Z, Lassen-Ramshad Y, Kirby K, Pedro C, Mikkelsen R, Di Pinto M, Høyer M, Stokkevåg CH. Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngioma Radiother Oncol . 2020 Jan;142:140-146 2020
  • Ervandian M, Djurhuus JC, Høyer M, Graugaard-Jensen C, Borre M Long-term urodynamic findings following radical prostatectomy and salvage radiotherapy Scand J Urol. 2018 Feb;52(1):20-26 2018
  • Poulsen PR, Murtaza G, Worm ES, Ravkilde T, O'Brien R, Grau C, Høyer M, Keall P Simulated multileaf collimator tracking for stereotactic liver radiotherapy guided by kilovoltage intrafraction monitoring: Dosimetric gain and target overdose trends Radiother Oncol 2020: 144; 93-100 2020
  • Nankali S, Worm ES, Hansen R, Weber B, Høyer M, Zirak A, Poulsen PR Geometric and dosimetric comparison of four intrafraction motion adaptation strategies for stereotactic liver radiotherapy Phys Med Biol 2018: 63; 145010 2018
  • Hansen AT, Poulsen PR, Høyer M, Worm ES Isotoxic dose prescription level strategies for stereotactic liver radiotherapy: the price of dose uniformity Acta Oncol 2020: 59: 558-64 2020
  • Skouboe S, Poulsen PR, Muurholm CG, Worm E, Hansen R, Høyer M, Ravkilde T. Simulated real-time dose reconstruction for moving tumors in stereotactic liver radiotherapy. Med Phys 2019: 46; 4738-4748. 2019
  • Haldbo-Classen L, Amidi A, Lukacova S, Wu LM, Oettingen GV, Lassen-Ramshad Y, Zachariae R, Kallehauge JF, Høyer M. Cognitive impairment following radiation to hippocampus and other brain structures in adults with primary brain tumours Radiother Oncol . 2020 Jul;148:1-7. 2020
  • Fodor A, Lancia A, Ceci F, Picchio M, Hoyer M, Jereczek-Fossa BA, Ost P, Castellucci P, Incerti E, Di Muzio N, Ingrosso G Oligorecurrent prostate cancer limited to lymph nodes: getting our ducks in a row : Nodal oligorecurrent prostate cancer World J Urol. 2019 Dec;37(12):2607-2613. 2019
  • Dobrzycka M, Spychalski P, Rostkowska O, Wilczyński M, Kobiela P, Grąt M, Dell'Acqua V, Høyer M, Jereczek-Fossa BA Stereotactic body radiation therapy for early-stage hepatocellular carcinoma - a systematic review on outcome Acta Oncol. 2019 Dec;58(12):1706-1713. 2019
  • Worm ES, Høyer M, Hansen R, Larsen LP, Weber B, Grau C, Poulsen PR. A Prospective Cohort Study of Gated Stereotactic Liver Radiation Therapy Using Continuous Internal Electromagnetic Motion Monitoring. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):366-375 2018
  • Boysen AK, Ording AG, Astradsson A, Høyer M, Spindler KL Metastasis directed treatment of brain metastases from colorectal cancer - a Danish population-based cohort study. Acta Oncol . 2020 Sep;59(9):1118-1122. 2020
  • Boysen AK, Spindler KL, Høyer M, Mortensen FV, Christensen TD, Farkas DK, Ording AG. Metastasis directed therapy for liver and lung metastases from colorectal cancer-A population-based study. Int J Cancer. 2018 Dec 15;143(12):3218-3226. 2018
  • Spychalski P, Kobiela J, Antoszewska M, Błażyńska-Spychalska A, Jereczek-Fossa BA, Høyer M. Patient specific outcomes of charged particle therapy for hepatocellular carcinoma - A systematic review and quantitative analysis. Radiother Oncol. 2019 Mar;132:127-134. 2019
  • Widmark A, Gunnlaugsson A, Beckman L, Thellenberg-Karlsson C, Hoyer M, Lagerlund M, Kindblom J, Ginman C, Johansson B, Björnlinger K, Seke M, Agrup M, Fransson P, Tavelin B, Norman D, Zackrisson B, Anderson H, Kjellén E, Franzén L, Nilsson P. Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial. Lancet. 2019 Aug 3;394(10196):385-395. 2019
  • Toussaint L, Indelicato DJ, Stokkevåg CH, Lassen-Ramshad Y, Pedro C, Mikkelsen R, Di Pinto M, Li Z, Flampouri S, Vestergaard A, Petersen JBB, Schrøder H, Høyer M, Muren LP Radiation doses to brain substructures associated with cognition in radiotherapy of pediatric brain tumors. Acta Oncol. 2019 Oct;58(10):1457-1462. 2019
  • Haldbo-Classen L, Amidi A, Wu LM, Lukacova S, Oettingen GV, Gottrup H, Zachariae R, Høyer M Long-term cognitive dysfunction after radiation therapy for primary brain tumors. Acta Oncol. 2019 May;58(5):745-752. 2019
  • Colvill E, Petersen JBB, Hansen R, Worm E, Skouboe S, Høyer M, Poulsen PR. Validation of fast motion-including dose reconstruction for proton scanning therapy in the liver. Phys Med Biol. 63(22):225021 2018
  • Schaub SK, Hartvigson PE, Lock MI, Høyer M, Brunner TB, Cardenes HR, Dawson LA, Kim EY, Mayr NA, Lo SS, Apisarnthanarax S. Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current Trends and Controversies. Technol Cancer Res Treat. 17:1533033818790217 2018
  • Lambrecht M, Eekers DBP, Alapetite C, Burnet NG, Calugaru V, Coremans IEM, Fossati P, Høyer M, Langendijk JA, Romero AM, Paulsen F, Perpar A, Renard L, de Ruysscher D2 Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Roelofs E, Nyström PW, Troost EGC; work package 1 of the taskforce “European Particle Therapy Network” of ESTRO. Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus. Radiother Oncol. 128(1), pp. 26-36 2018
  • Eekers DB, In 't Ven L, Roelofs E, Postma A, Alapetite C, Burnet NG, Calugaru V, Compter l, Coremans IEM, Høyer M, Lambrecht M, Nyström PW, Romero AM, Paulsen F, Perpar A, de Ruysscher D, Renard L, Timmermann B, Vitek P, Weber DC, van der Weide HL, Whitfield GA, Wiggenraad R, Troost EGC; “European Particle Therapy Network” of ESTRO. The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology. Radiother Oncol. 128(1), pp. 37-43 2018
  • Thor M, Jackson A, Zelefsky MJ, Steineck G, Karlsdòttir A, Høyer M, Liu M, Nasser NJ, Petersen SE, Moiseenko V, Deasy JO Inter-institutional analysis demonstrates the importance of lower than previously anticipated dose regions to prevent late rectal bleeding following prostate radiotherapy. Radiother Oncol. 127(1), pp. 88-95 2018
  • Skouboe S, Ravkilde T, Bertholet J, Hansen R, Worm ES, Muurholm CG, Weber B, Høyer M, Poulsen PR. First clinical real-time motion-including tumor dose reconstruction during radiotherapy delivery. Radiother Oncol. 2019 Oct;139:66-71. 2019
  • Mortensen HR, Høyer M, Grau C. Proton therapy Ugeskr Laeger. 2019 Oct 14;181(20A). 2019
  • Bertholet J, Toftegaard J, Hansen R, Worm ES, Wan H, Parikh PJ, Weber B, Høyer M, Poulsen PR. Automatic online and real-time tumour motion monitoring during stereotactic liver treatments on a conventional linac by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK). Phys Med Biol. 63(5); pp. 055012 2018
  • Overgaard J, Muren LP, Høyer M, Grau C BIGART 2019 - adapting to the future. Acta Oncol. 2019 Oct;58(10):1323-1327. 2019
  • Petersen SE, Thorsen LB, Hansen S, Petersen PM, Lindberg H, Moe M, Petersen JB, Muren LP, Høyer M, Bentzen L A phase I/II study of acute and late physician assessed and patient-reported morbidity following whole pelvic radiation in high-risk prostate cancer patients Acta Oncol . 2022 Feb;61(2):179-184 2022
  • Toussaint L, Peters S, Mikkelsen R, Karabegovic S, Bäumer C, Muren LP, Tram-Henriksen L, Høyer M, Lassen-Ramshad Y, Timmermann B Delineation atlas of the Circle of Willis and the large intracranial arteries for evaluation of doses to neurovascular structures in pediatric brain tumor patients treated with radiation therapy Acta Oncol . 2021 Nov;60(11):1392-1398 2021
  • Bergfeldt K, Nystrom H, Witt Nystrom P, Høyer M Is there a Nordic solution for the 'proton-problem'? Acta Oncol. 2020 Oct;59(10):1137-1138 2020
  • Brandal P, Bergfeldt K, Aggerholm-Pedersen N, Bäckström G, Kerna I, Gubanski M, Björnlinger K, Evensen ME, Kuddu M, Pettersson E, Brydøy M, Hellebust TP, Dale E, Valdman A, Weber L, Høyer M A Nordic-Baltic perspective on indications for proton therapy with strategies for identification of proper patients Acta Oncol. 2020 Oct;59(10):1157-1163 2020
  • Ingrosso G, Becherini C, Lancia A, Caini S, Ost P, Francolini G, Høyer M, Bottero M, Bossi A, Zilli T, Scartoni D, Livi L, Santoni R, Giacomelli I, Detti B Nonsurgical Salvage Local Therapies for Radiorecurrent Prostate Cancer: A Systematic Review and Meta-analysis Eur Urol Oncol. 2020 Apr;3(2):183-197 2020
  • Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document Radiother Oncol. 2020 Jul;148:157-166 2020
  • Zaer H, Glud AN, Schneider BM, Lukacova S, Vang Hansen K, Adler JR, Høyer M, Jensen MB, Hansen R, Hoffmann L, Worm ES, Sørensen JCH, Orlowski D Radionecrosis and cellular changes in small volume stereotactic brain radiosurgery in a porcine model Sci Rep. 2020 Oct 1;10(1):16223 2020
  • Bjerre HL, Kronborg MB, Nielsen JC, Høyer M, Jensen MF, Zaremba T, Lægdsmand PMT, Søndergaard CS, Nyström H, Kronborg CJS Risk of Cardiac Implantable Electronic Device Malfunctioning During Pencil Beam Proton Scanning in an In Vitro Setting Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):186-195 2021
  • Fransson P, Nilsson P, Gunnlaugsson A, Beckman L, Tavelin B, Norman D, Thellenberg-Karlsson C, Hoyer M, Lagerlund M, Kindblom J, Ginman C, Johansson B, Björnlinger K, Seke M, Agrup M, Zackrisson B, Kjellén E, Franzén L, Widmark A. Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer (HYPO-RT-PC): patient-reported quality-of-life outcomes of a randomised, controlled, non-inferiority, phase 3 trial. Lancet Oncol. 2021 Feb;22(2):235-245 2021
  • Haldbo-Classen L, Amidi A, Wu LM, Lukacova S, Oettingen G, Lassen-Ramshad Y, Zachariae R, Kallehauge JF, Høyer M. Associations between patient-reported outcomes and radiation dose in patients treated with radiation therapy for primary brain tumours Clin Transl Radiat Oncol. 2021 Sep 27;31:86-92 2021
  • Høyer M, Grau C Research in radiation oncology and the Covid-19 pandemic Acta Oncol. 2021 Mar;60(3):275-276 2021
  • Petersen SE, Høyer M Androgen Deprivation Therapy Combined With Particle Therapy for Prostate Cancer: A Systematic Review Front Oncol. 2021 Jun 23;11:695647 2021
  • Sørensen BS, Pawelke J, Bauer J, Burnet NG, Dasu A, Høyer M, Karger CP, Krause M, Schwarz M, Underwood TSA, Wagenaar D, Whitfield GA, Lühr A Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy? Radiother Oncol. 2021 Oct;163:177-184 2021
  • Sørensen M, Fode MM, Petersen JB, Holt MI, Høyer M Effect of stereotactic body radiotherapy on regional metabolic liver function investigated in patients by dynamic [18F]FDGal PET/CT Radiat Oncol. 2021 Oct 1;16(1):192 2021
  • Andratschke N, Willmann J, Appelt AL, Alyamani N, Balermpas P, Baumert BG, Hurkmans C, Høyer M, Langendijk JA, Kaidar-Person O, van der Linden Y, Meattini I, Niyazi M, Reynaert N, De Ruysscher D, Tanadini-Lang S, Hoskin P, Poortmans P, Nieder C European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making Lancet Oncol. 2022 Oct;23(10):e469-e478 2022
  • Barcellini A, Massaro M, Dal Mas F, Langendijk JA, Høyer M, Calugaru V, Haustermans K, Timmermann B, Thariat J, Scartoni D, Vennarini S, Georg P, Orlandi E. A year of pandemic for European particle radiotherapy: A survey on behalf of EPTN working group Clin Transl Radiat Oncol. 2022 Feb 24;34:1-6 2022
  • Thuehøj AU, Andersen NC, Worm ES, Høyer M, Tabaksblat EM, Weber B, Mortensen HR Clinical outcomes after stereotactic ablative radiotherapy in locally advanced cholangiocarcinoma Acta Oncol. 2022 Feb;61(2):197-201 2022
  • Tambas M, van der Laan HP, Steenbakkers RJHM, Doyen J, Timmermann B, Orlandi E, Hoyer M, Haustermans K, Georg P, Burnet NG, Gregoire V, Calugaru V, Troost EGC, Hoebers F, Calvo FA, Widder J, Eberle F, van Vulpen M, Maingon P, Skóra T, Weber DC, Bergfeldt K, Kubes J, Langendijk JA Current practice in proton therapy delivery in adult cancer patients across Europe Radiother Oncol. 2022 Feb;167:7-13 2022
  • Stick LB, Lægdsmand PMT, Bjerre HL, Høyer M, Jensen K, Jensen MF, Kronborg MB, Offersen BV, Kronborg CJS Spot-scanning proton therapy for targets with adjacent cardiac implantable electronic devices - Strategies for breast and head & neck cancer Phys Imaging Radiat Oncol. 2022 Feb 19;21:66-71 2022
  • Fuglsang Jensen M, Stick LB, Høyer M, Kronborg CJS, Lorenzen EL, Mortensen HR, Nyström PW, Petersen SE, Randers P, Thai LMH, Yates ES, Offersen BV. Proton therapy for early breast cancer patients in the DBCG proton trial: planning, adaptation, and clinical experience from the first 43 patients Acta Oncol. 2022 Feb;61(2):223-230 2022