
Brita Singers Sørensen
Professor, PhD Experimental Clinical Oncology, Aarhus University Hospital bsin@oncology.au.dkDK: Eksperimentel Radiobiologi. Partikel radiobiologi. Dyremodeller. In vitro studier. Biomarkører
UK: Experimental radiobiology. Particle radiobiology. Animal models. In vitro studies. Biomarkers.
Workgroups Publications- Time structure of pencil beam scanning proton FLASH beams measured with scintillator detectors and compared with log files Med Phys . 2022 Mar;49(3):1932-1943 2022
- Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts Cancers (Basel) . 2021 May 26;13(11):2602 2021
- Therapeutic Modification of Hypoxia Clin Oncol (R Coll Radiol) . 2021 Nov;33(11):e492-e509 2021
- Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone? Int J Hyperthermia . 2021;38(1):105-110 2021
- Hypoxia and local tumour control in squamous cell carcinoma of the anus - a hypothesis-generating study Acta Oncol . 2022 Jun 22;1-4 2022
- Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways Front Oncol . 2020 Apr 21;10:562 2020
- Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Front Phys 2020: 8; 565055. 2020
- Proton Scanning and X-ray Beam Irradiation Induce Distinct Regulation of Inflammatory Cytokines in a Preclinical Mouse Model Int J Radiat Biol. 2020 Oct;96(10):1238-1244. 2020
- Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence. Radiother Oncol . 2020 Jul 3;150:211-216. 2020
- Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons. Int J Radiat Oncol Biol Phys. 2018 Dec 6 2018
- IMRT - Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer. Oral Oncol. 2018 Nov;86:91-99. 2018
- Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer. Clin Chim Acta. 2018 Dec;487:107-111. 2018
- Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia. Cancers (Basel). 2019 Jan 9;11(1). 2019
- Commentary: RBE in proton therapy - where is the experimental in vivo data? Acta Oncol. 2019 Oct;58(10):1337-1339. 2019
- Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial. Acta Oncol. 2018 Sep;57(9):1159-1164 2018
- Circulating cell-free DNA as predictor of pathological complete response in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy Clin Transl Radiat Oncol. 2022 Jun 8;36:9-15 2022
- Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group Radiother Oncol. 2018 Jul;128(1):14-18 2018
- “Radiobiology of Proton Therapy”. "Radiobiology of Proton Therapy": Results of an international expert workshop Radiother Oncol. 2018 Jul;128(1):56-67 2018
- Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts. Sci Rep. 2018 Aug 23;8(1):12688. 2018
- Comparing Photon and Charged Particle Therapy Using DNA Damage Biomarkers Int J Part Ther. 2018 Summer;5(1):15-24 2018
- Circulating cell-free DNA as predictor of treatment failure after neoadjuvant chemo-radiotherapy before surgery in patients with locally advanced rectal cancer. Ann Oncol. 2018 Mar 1;29(3):610-615 2018
- Prognostic value of a 15-gene hypoxia classifier in oropharyngeal cancer treated with accelerated chemoradiotherapy Strahlenther Onkol. 2020 Jun;196(6):552-560 2020
- Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy? Radiother Oncol. 2021 Oct;163:177-184 2021
- A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE) Radiother Oncol. 2022 Oct;175:79-92 2022
- Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model Radiother Oncol. 2022 Oct;175:178-184 2022
- In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH Radiother Oncol. 2022 Feb;167:109-115 2022
- Time-resolved dose rate measurements in pencil beam scanning proton FLASH therapy with a fiber-coupled scintillator detector system Med Phys. 2022 Dec 12 2022
- Clinical use and future requirements of relative biological effectiveness: Survey among all European proton therapy centres Radiother Oncol. 2022 Jul;172:134-139 2022
- The current status of preclinical proton FLASH radiation and future directions Med Phys. 2022 Mar;49(3):2039-2054 2022