Research interests

DK: Eksperimentel Radiobiologi. Partikel radiobiologi. Dyremodeller. In vitro studier. Biomarkører

UK: Experimental radiobiology. Particle radiobiology. Animal models. In vitro studies. Biomarkers.

Workgroups

• WP10 - Radiobiology
• WP1 - Biomarkers (molecular and imaging)

Publications

• Kanouta E, Johansen JG, Kertzscher G, Sitarz MK, Sørensen BS, Poulsen PR Time structure of pencil beam scanning proton FLASH beams measured with scintillator detectors and compared with log files Med Phys . 2022 Mar;49(3):1932-1943 2022
• Elming PB, Wittenborn TR, Busk M, Sørensen BS, Thomsen MBH, Strandgaard T, Dyrskjøt L, Nielsen S, Horsman MR Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts Cancers (Basel) . 2021 May 26;13(11):2602 2021
• Horsman MR, Sørensen BS, Busk M, Siemann DW Therapeutic Modification of Hypoxia Clin Oncol (R Coll Radiol) . 2021 Nov;33(11):e492-e509 2021
• Elming PB, Sørensen BS, Spejlborg H, Overgaard J, Horsman MR Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone? Int J Hyperthermia . 2021;38(1):105-110 2021
• Lefèvre AC, Alsner J, Sørensen BS, Tramm T, Toustrup K, Overgaard J, Spindler KG Hypoxia and local tumour control in squamous cell carcinoma of the anus - a hypothesis-generating study Acta Oncol . 2022 Jun 22;1-4 2022
• Sørensen BS, Horsman MR Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways Front Oncol . 2020 Apr 21;10:562 2020
• Henthorn NT, Sokol O, Durante M, De Marzi L, Pouzoulet F, Miszczyk J, Olko P, Brandenburg S, van Goethem MJ, Barazzuol L, Tambas M, Langendijk JA, Davídková M, Vondráček V, Bodenstein E, Pawelke J, Lomax A, Weber DC, Dasu A,Sternlöw B, Poulsen PR, Sørensen BS, Grau C, Sitarz MK, Heuskin AC, Lucas S, Warmenhoven JW, Merchant MJ, Mackay RI, Kirkby KJ. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Front Phys 2020: 8; 565055. 2020
• Nielsen S, Bassler N, Grzanka L, Swakon J, Olko P, Horsman MR, Sørensen BS Proton Scanning and X-ray Beam Irradiation Induce Distinct Regulation of Inflammatory Cytokines in a Preclinical Mouse Model Int J Radiat Biol. 2020 Oct;96(10):1238-1244. 2020
• Lefèvre AC, Kronborg C, Sørensen BS, Krag SRP, Serup-Hansen E, Spindler KG. Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence. Radiother Oncol . 2020 Jul 3;150:211-216. 2020
• Nielsen S, Bassler N, Grzanka L, Laursen L, Swakon J, Olko P, Andreassen CN, Alsner J, Singers Sørensen B. Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons. Int J Radiat Oncol Biol Phys. 2018 Dec 6 2018
• Andreassen CN, Eriksen JG, Jensen K, Hansen CR, Sørensen BS, Lassen P, Alsner J, Schack LMH, Overgaard J, Grau C. IMRT - Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer. Oral Oncol. 2018 Nov;86:91-99. 2018
• Boysen AK, Sørensen BS, Lefevre AC, Abrantes R, Johansen JS, Jensen BV, Schou JV, Larsen FO, Nielsen D, Taflin H, Gustavson B, Wettergren Y, Sorensen BS, Ree AH, Dueland S, Pallisgaard N, Spindler KL Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer. Clin Chim Acta. 2018 Dec;487:107-111. 2018
• Elming PB, Sørensen BS, Oei AL, Franken NAP, Crezee J, Overgaard J, Horsman MR Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia. Cancers (Basel). 2019 Jan 9;11(1). 2019
• Sørensen BS Commentary: RBE in proton therapy - where is the experimental in vivo data? Acta Oncol. 2019 Oct;58(10):1337-1339. 2019
• Brøndum L, Alsner J, Sørensen BS, Maare C, Johansen J, Primdahl H, Evensen JF, Kristensen CA, Andersen LJ, Overgaard J, Eriksen JG Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial. Acta Oncol. 2018 Sep;57(9):1159-1164 2018
• Truelsen CG, Kronborg CS, Sørensen BS, Callesen LB, Spindler KG Circulating cell-free DNA as predictor of pathological complete response in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy Clin Transl Radiat Oncol. 2022 Jun 8;36:9-15 2022
• Dosanjh M, Jones B, Pawelke J, Pruschy M, Sørensen BS Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group Radiother Oncol. 2018 Jul;128(1):14-18 2018
• Lühr A, von Neubeck C, Pawelke J, Seidlitz A, Peitzsch C, Bentzen SM, Bortfeld T, Debus J, Deutsch E, Langendijk JA, Loeffler JS, Mohan R, Scholz M, Sørensen BS, Weber DC, Baumann M, Krause M; “Radiobiology of Proton Therapy”. "Radiobiology of Proton Therapy": Results of an international expert workshop Radiother Oncol. 2018 Jul;128(1):56-67 2018
• Nielsen S, Bassler N, Grzanka L, Swakon J, Olko P, Andreassen CN, Alsner J, Sørensen BS. Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts. Sci Rep. 2018 Aug 23;8(1):12688. 2018
• Ray S, Cekanaviciute E, Lima IP, Sørensen BS, Costes SV. Comparing Photon and Charged Particle Therapy Using DNA Damage Biomarkers Int J Part Ther. 2018 Summer;5(1):15-24 2018
• Schou JV, Larsen FO, Sørensen BS, Abrantes R, Boysen AK, Johansen JS, Jensen BV, Nielsen DL, Spindler KL. Circulating cell-free DNA as predictor of treatment failure after neoadjuvant chemo-radiotherapy before surgery in patients with locally advanced rectal cancer. Ann Oncol. 2018 Mar 1;29(3):610-615 2018
• Deschuymer S, Sørensen BS, Dok R, Laenen A, Hauben E, Overgaard J, Nuyts S Prognostic value of a 15-gene hypoxia classifier in oropharyngeal cancer treated with accelerated chemoradiotherapy Strahlenther Onkol. 2020 Jun;196(6):552-560 2020
• Sørensen BS, Pawelke J, Bauer J, Burnet NG, Dasu A, Høyer M, Karger CP, Krause M, Schwarz M, Underwood TSA, Wagenaar D, Whitfield GA, Lühr A Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy? Radiother Oncol. 2021 Oct;163:177-184 2021
• Underwood TSA, McNamara AL, Appelt A, Haviland JS, Sørensen BS, Troost EGC A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE) Radiother Oncol. 2022 Oct;175:79-92 2022
• Sørensen BS, Sitarz MK, Ankjærgaard C, Johansen JG, Andersen CE, Kanouta E, Grau C, Poulsen P Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model Radiother Oncol. 2022 Oct;175:178-184 2022
• Singers Sørensen B, Krzysztof Sitarz M, Ankjærgaard C, Johansen J, Andersen CE, Kanouta E, Overgaard C, Grau C, Poulsen P In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH Radiother Oncol. 2022 Feb;167:109-115 2022
• Kanouta E, Poulsen PR, Kertzscher G, Sitarz MK, Sørensen BS, Johansen JG Time-resolved dose rate measurements in pencil beam scanning proton FLASH therapy with a fiber-coupled scintillator detector system Med Phys. 2022 Dec 12 2022
• Heuchel L, Hahn C, Pawelke J, Sørensen BS, Dosanjh M, Lühr A Clinical use and future requirements of relative biological effectiveness: Survey among all European proton therapy centres Radiother Oncol. 2022 Jul;172:134-139 2022
• Diffenderfer ES, Sørensen BS, Mazal A, Carlson DJ The current status of preclinical proton FLASH radiation and future directions Med Phys. 2022 Mar;49(3):2039-2054 2022